Table 4

Grade assessment of sputum eosinophil-based papers

• GRADE Working Group grades of evidence.

• High quality: further research is very unlikely to change our confidence in the estimate of effect.

• Moderate quality: further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.

• Low quality: further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.

• Very low quality: we are very uncertain about the estimate.

• * The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% CI) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).

• 1 One paper (Chlumsky) was open labelled with no blinding.

• 2 Two studies (Chlumsky and Green) had significantly higher doses of ICS overall.

• ICS, inhaled corticosteroid.