Table 3

T-cell reactivity (IFNγ and IL-2) on PMBCs of 45 subjects against elastin peptides, collagen I peptides and collagen V peptides, stratified according to COPD status

	Non-smoking controls	Smoking controls	COPD	p Value
No. of subjects	11	10	24
Elastin peptides
IFNγ expression (ratio)	1.4 (0.9–2.4)	2.0 (1.4–5.4)	2.8 (1.4–4.7)	0.150
IL-2 expression (ratio)	0.9 (0.9–1.5)	1.4 (1.0–1.8)	1.0 (0.7–1.3)	0.123
Collagen I peptides
IFNγ expression (ratio)	1.3 (0.9–1.9)	1.4 (1.0–2.6)	2.1 (0.9–3.3)	0.478
IL-2 expression (ratio)	1.2 (0.6–1.4)	1.0 (0.8–1.9)	1.0 (0.7–1.3)	0.637
Collagen V peptides
IFNγ expression (ratio)	1.7 (1.3–5.2)	5.5 (3.8–21.6)	8.0 (3.4–20.7)	0.008*
IL-2 expression (ratio)	0.7 (0.6–1.1)	1.2 (0.9–1.7)	1.1 (0.8–1.6)	0.164

Data are presented as median (IQR). Kruskall–Wallis p values are reported.
*p<0.05.
COPD, chronic obstructive pulmonary disease; IFN, interferon; IL, interleukin; PBMC, peripheral blood mononuclear cell.