Demographic and desmosine data for group 1 consisting of healthy volunteers and patients with stable chronic obstructive pulmonary disease (COPD) and asthma
| Sample type | Group 1 | ||||
| Blood, urine and sputum | |||||
| Group | Healthy volunteers: non-smokers | Healthy volunteers: smokers | Asthma: non-smokers | Asthma: smokers | Stable COPD |
| Number of participants | 26 | 20 | 53 | 56 | 53 |
| Gender (M/F) | 8/18 | 9/11 | 22/31 | 27/29 | 23/30 |
| Smoking status (smokers/ex-smokers/non-smokers) | 0/0/26 | 20/0/0 | 0/0/53 | 56/0/0 | 28/25/0 |
| Age (years) | 51±13 | 52±9 | 46±12 | 47±10 | 65±7* |
| Body mass index | 27 (22–28) | 27 (21–30) | 28 (25–36) | 26 (23–30) | 27 (23–30) |
| FEV1 (% predicted) | 106 (95–115) | 93 (88–100) | 79 (70–91)† | 78 (58–93)† | 62 (44–77)‡ |
| TLCO%COHb | NA | NA | 86±11 | 77±18§ | 60±15¶ |
| uDES (ng/mg creatinine) | 9 (8–13) | 11 (9–15) | 8 (6–10) | 10 (7–13) | 11 (9–15)** |
| bDES (ng/ml) | 0.21 (0.19–0.24) | 0.23 (0.19–0.26) | 0.21 (0.19–0.25) | 0.22 (0.19–0.25) | 0.29 (0.24–0.35)* |
Data are shown as median (IQR) or mean ± SD based on whether data were normally distributed. Kruskal–Wallis analysis of variance (ANOVA) with Dunn's method for pairwise multiple comparison or one-way ANOVA with Tukey's method was used.
↵* p<0.001, versus other four groups.
↵† p<0.05, versus healthy non-smokers and smokers.
↵‡ p<0.001 versus healthy non-smokers and smokers; p<0.05 versus non-smokers and smokers with asthma.
↵§ p<0.001, versus non-smokers with asthma and patients with COPD.
↵¶ p<0.001, versus non-smokers and smokers with asthma.
↵** p<0.01 versus non-smokers with asthma.
bDES, blood desmosine; FEV1, forced expiratory volume in 1 s; TLCO%COHb, transfer factor corrected for haemoglobin and carboxy haemoglobin; uDES, urinary desmosine.