Table 2

Change in lung function, as measured every 3 months, patients with COPD and the comparator groups

Spirometric variableVisit (months)NSCSCPatients with COPDp Values
NSC vs SCNCS vs patients with COPDSC vs patients with COPD
Post-bronchodilator FEV1 change (litres)00.08 (0.14)0.14 (0.15)0.12 (0.15)<0.001<0.0010.110
30.09 (0.16)0.11 (0.22)0.12 (0.14)0.059<0.0010.308
60.08 (0.14)0.12 (0.13)0.13 (0.15)0.002<0.0010.893
120.07 (0.17)0.11 (0.14)0.12 (0.14)0.002<0.0010.201
Post-bronchodilator FVC change (litres)0–0.00 (0.20)0.01 (0.22)0.25 (0.34)0.656<0.001<0.001
3–0.01 (0.22)0.01 (0.31)0.25 (0.32)0.464<0.001<0.001
6–0.01 (0.20)0.03 (0.19)0.24 (0.32)0.111<0.001<0.001
12–0.02 (0.19)0.02 (0.17)0.23 (0.31)0.197<0.001<0.001
Post-bronchodilator FEV1/FVC change (%)02.13 (3.46)2.98 (4.25)0.29 (4.35)0.025<0.001<0.001
32.29 (3.93)2.51 (3.41)0.35 (4.15)0.542<0.001<0.001
62.42 (3.20)2.45 (3.29)0.61 (4.43)0.923<0.001<0.001
121.93 (4.20)2.31 (3.59)0.71 (4.13)0.291<0.001<0.001
  • Data are given as mean (SD).

  • COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity; NCS, non-smoker control; SC, smoker control.