Associations with persistence of bronchiectasis
| Clinical factors | Change in bronchiectasis status | Model 1* | Model 2† | |||
| Transient | Persistent | OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Age | 2.0 (1.2–3.3) | 3.1 (1.9–4.0) | 1.23 (0.91 to 1.66) | 0.169 | 1.30 (0.95 to 1.79) | 0.101 |
| Sex (female) | 53% (19/35) | 57% (56/98) | 1.17 (0.53 to 2.57) | 0.703 | – | – |
| Severe CFTR genotype | 88% (28/32) | 96% (86/90) | 3.03 (0.69 to 13.29) | 0.142 | – | – |
| Pancreatic sufficiency | 20% (7/35) | 10% (10/98) | 0.51 (0.17 to 1.49) | 0.219 | – | – |
| Respiratory symptoms at the initial scan | 20% (7/35) | 30% (29/98) | 1.61 (0.63 to 4.12) | 0.320 | – | – |
| Respiratory symptoms at the subsequent scan | 9% (3/33) | 29% (27/98) | 3.86 (1.06 to 14.00) | 0.040 | – | – |
| CT factors | ||||||
| Detectable air trapping at the initial scan | 69% (24/35) | 86% (84/98) | 2.72 (1.08 to 6.86) | 0.034 | – | – |
| Air trapping extent at the initial scan | 3 (0–6) | 4 (2–9) | 2.83 (1.22 to 6.54) | 0.015 | – | – |
| Detectable air trapping at the subsequent scan | 57% (20/35) | 80% (79/98) | 1.18 (1.02 to 1.36) | 0.029 | – | – |
| Air trapping extent at the subsequent scan | 1 (0–6) | 4.5 (1–9) | 1.24 (1.07 to 1.44) | 0.004 | – | – |
| Change in air trapping extent | 0 (−1–2) | 0 (−1–4) | 1.21 (1.02 to 1.45) | 0.032 | – | – |
| Bronchiectasis extent at the initial scan | 2 (1–6) | 3 (1–7) | 1.85 (0.73 to 4.68) | 0.257 | – | – |
| Bronchoalveolar lavage factors at the initial scan | ||||||
| Uninfected | 34% (12/35) | 23% (22/97) | (Comparator) | (Comparator) | ||
| Mixed oral flora | 26% (9/35) | 25% (24/97) | 1.55 (0.54 to 4.44) | 0.412 | 1.73 (0.50 to 5.96) | 0.387 |
| Infected | 40% (14/35) | 53% (51/97) | 1.85 (0.73 to 4.68) | 0.195 | 1.51 (0.46 to 5.00) | 0.501 |
| Detectable neutrophil elastase | 38% (13/35) | 42% (41/97) | 1.16 (0.52 to 2.58) | 0.725 | – | – |
| Inflammatory response score | −0.01 (−0.80–0.88) | 0.55 (−0.74–1.44) | 1.17 (0.90 to 1.53) | 0.238 | 0.99 (0.69 to 1.41) | 0.949 |
| Bronchoalveolar lavage factors at the subsequent scan | ||||||
| Uninfected | 40% (14/35) | 22% (12/98) | (Comparator) | (Comparator) | ||
| Mixed oral flora | 20% (7/35) | 20% (20/98) | 4.33 (1.28 to 14.68) | 0.018 | 3.34 (0.86 to 12.90) | 0.080 |
| Infected | 40% (14/35) | 67% (66/98) | 6.23 (2.29 to 16.93) | <0.001 | 4.92 (1.51 to 16.00) | 0.008 |
| Detectable neutrophil elastase | 23% (8/35) | 49% (48/98) | 3.22 (1.32 to 7.84) | 0.010 | – | – |
| Inflammatory response score | −0.20 (−1.36–0.69) | 0.78 (−0.43–1.96) | 1.43 (1.09 to 1.88) | 0.010 | 1.30 (0.92 to 1.82) | 0.134 |
| Change in inflammatory response score | 0.27 (−1.49–1.04) | 0.35 (−0.86–1.33) | 1.50 (1.09 to 2.04) | 0.011 | – | – |
Data given as median (25th–75th percentile) or percentage (raw data) as appropriate.
–Not included in model. Bold, significant p-values (<0.05).
↵* Model 1: Each variable analysed in a separate model after adjusting for age at the initial scan.
↵† Model 2: Combined model adjusted for age at initial scan, infection status at the initial and subsequent scans and inflammation status at the initial and subsequent scans.
CFTR, cystic fibrosis transmembrane regulator.