Comparison between two published ranges (5th–95th percentiles) of α1-antitrypsin serum levels according to different phenotypes (PI),1 one in μM and one in g/litre,6 and the range, according to different genotypes (PI*), as deduced by our analysis2
Phenotype–genotype | Units | Reference ranges1 | Present paper2 |
PI MM–PI*MM | μM | 20–48 | 20.2–31.5 |
g/l | 1.50–3.50 | 1.05–1.64 | |
PI SS–PI*SS | μM | 15–33 | 14.0–20.4 |
g/l | 1.00–2.00 | 0.73–1.06 | |
PI MZ–PI*MZ | μM | 17–33 | 12.7–19.2 |
g/l | 0.90–2.10 | 0.66–1.00 | |
PI SZ–PI*SZ | μM | 8–16 | 9.4–12.7 |
g/l | 0.75–1.20 | 0.49–0.66 |
The g/litre values in our analysis were mathematically converted to μM, based on a molecular weight of 52 kDa. Note that the PI*MS data are not present because this genotype was not included in the original American Thoracic Society/European Respiratory Society guidelines.