Algorithm for treatment changes in the symptom and inflammatory management groups
| Increase treatment | No change in treatment | Decrease treatment | |
| Symptom management group | |||
| Number of major exacerbations (courses of OCS) | >1 | ≤1 | ≤1 |
| OR | AND | AND | |
| SABA usage (times per week) | >5 | 3–5 | <3 |
| Inflammatory management group | |||
| Sputum eosinophils, % | >2.5 | 0.1–2.5 | <0.1 |
| OR | OR | OR | |
| FENO, ppb (if no sputum sample available) | >30 | 22–30 | <22 |
FENO, exhaled nitric oxide; OCS, oral corticosteroids; SABA, short-acting β agonist.