Associations with progression of air trapping
| Clinical factors | Model 1* | Model 2† | ||
| Regression coefficient‡ (95% CI) | p Value | Regression coefficient‡ (95% CI) | p Value | |
| Age | 0.97 (0.92 to 1.02) | 0.209 | 0.92 (0.88 to 0.98) | 0.004 |
| Sex (female) | 1.07 (0.91 to 1.27) | 0.419 | – | – |
| Severe CFTR genotype | 1.40 (1.14 to 1.71) | 0.001 | 1.40 (1.07 to 1.81) | 0.012 |
| Pancreatic sufficiency | 0.87 (0.69 to 1.10) | 0.240 | – | – |
| Respiratory symptoms at the initial scan | 1.00 (0.83 to 1.21) | 0.983 | – | – |
| Respiratory symptoms at the subsequent scan | 1.18 (0.97 to 1.42) | 0.091 | – | – |
| CT factors | ||||
| Detectable bronchiectasis at the initial scan | 1.05 (0.88 to 1.26) | 0.575 | – | – |
| Bronchiectasis extent at the initial scan | 1.05 (1.01 to 1.09) | 0.008 | – | – |
| Detectable bronchiectasis at the subsequent scan | 1.39 (1.16 to 1.65) | <0.001 | – | – |
| Bronchiectasis extent at the subsequent scan | 1.08 (1.05 to 1.11) | <0.001 | – | – |
| Change in bronchiectasis extent | 1.07 (1.04 to 1.10) | <0.001 | – | – |
| Bronchoalveolar lavage factors at the initial scan | ||||
| Uninfected | (Comparator) | (Comparator) | ||
| Mixed oral flora | 0.95 (0.76 to 1.17) | 0.609 | 0.84 (0.68 to 1.03) | 0.098 |
| Infected | 1.05 (0.87 to 1.27) | 0.613 | 0.86 (0.68 to 1.03) | 0.171 |
| Detectable neutrophil elastase | 1.13 (0.96 to 1.33) | 0.147 | – | – |
| Inflammatory response score | 1.08 (1.02 to 1.15) | 0.005 | 1.06 (0.99 to 1.13) | 0.124 |
| Bronchoalveolar lavage factors at the subsequent scan | ||||
| Uninfected | (Comparator) | (Comparator) | ||
| Mixed oral flora | 1.09 (0.83 to 1.43) | 0.548 | 1.06 (0.80 to 1.42) | 0.671 |
| Infected | 1.32 (1.06 to 1.64) | 0.014 | 1.15 (0.87 to 1.51) | 0.321 |
| Detectable neutrophil elastase | 1.48 (1.26 to 1.75) | <0.001 | – | – |
| Inflammatory response score | 1.11 (1.05 to 1.18) | <0.001 | 1.09 (1.02 to 1.17) | 0.017 |
| Change in inflammatory response score | 1.10 (1.03 to 1.17) | 0.004 | – | – |
–Not included in model. Bold, significant p-values (<0.05).
↵* Model 1: Each variable analysed in a separate model after adjusting for age at the initial scan and severe CFTR genotype.
↵† Model 2: Combined model adjusted for age at initial scan, severe CFTR genotype, infection status at the initial and subsequent scans and inflammation status at the initial and subsequent scans.
↵‡ Regression coefficients have been back-transformed from the logarithmic scale.
CFTR, cystic fibrosis transmembrane regulator.