Table 2

Grades of recommendation

GradeType of evidence
A
  • At least one meta-analysis, systematic review, or RCT rated as 1++ and directly applicable to the target population or

  • A systematic review of RCTs or a body of evidence consisting principally of studies rated as 1+ directly applicable to the target population and demonstrating overall consistency of results

B
  • A body of evidence including studies rated as 2++ directly applicable to the target population and demonstrating overall consistency of results or

  • Extrapolated evidence from studies rated as 1++ or 1+

C
  • A body of evidence including studies rated as 2+ directly applicable to the target population and demonstrating overall consistency of results or

  • Extrapolated evidence from studies rated as 2++

D
  • Evidence level 3 or 4 or

  • Extrapolated evidence from studies rated as 2+

Important practical points for which there is no research evidence, nor is there likely to be any research evidence. The Guideline Committee wishes to emphasise these as good practice points
  • RCT, randomised controlled trial.