Table 3

Top 10 downregulated microRNAs in lungs from subjects with COPD compared with smokers without COPD

miRNAFold difference (COPD/normal smokers)p ValuepFDR value
hsa-miR-923−5.065.88E-062.91E-05
hsa-miR-937−2.361.89E-061.08E-05
hsa-miR-422a−2.121.45E-068.74E-06
hsa-miR-576-3p−2.061.57E-069.22E-06
hsa-miR-513a-5p−2.063.57E-048.54E-04
hsa-miR-25*−2.012.10E-071.56E-06
hsa-miR-99b*−1.811.23E-055.25E-05
hsa-miR-125b-1*−1.751.38E-055.70E-05
hsa-miR-24−1.751.59E-044.49E-04
hsa-miR-187*−1.643.14E-048.04E-04
  • * indicates miRNA on the opposite arm of the hairpin during processing.

  • COPD, chronic obstructive pulmonary disease; pFDR, positive false discovery rate.