Table 3

VX-809 Pharmacokinetic parameters following once-daily dosing of VX-809 for 28 days

Dose	Parameter	Day 1			Day 28						Day 28/day 1
Dose	Parameter	C_max (μg/ml)	t_max (h)	AUC_{0–24 h} (μg×h/ml)	C_max (μg/ml)	t_max^* (h)	AUC_{0–24 h} (μg×h/ml)	CL_ss/F (l/h)	V_z/F (litres)	t_1/2λz (h)	AUC AR
25 mg	n	18	18	18	17	17	17	17	17	17	17
	Mean	0.760	3.5^*	7.20	1.10	4.0^*	12.9	2.20	62.6	18.3	1.85
	SD	0.280	1.5–9.0^†	2.19	0.44	2.9–12.0^†	4.9	0.80	99.0	20.5	0.70
50 mg	n	18	18	18	17	17	17	17	17	17	17
	Mean	1.85	3.1^*	16.6	2.66	3.1^*	28.8	2.31	54.6	17.3	1.67
	SD	0.70	1.5–12.1^†	6.3	1.01	0.8–9.0^†	13.1	1.48	35.2	8.9	0.49
100 mg	n	17	17	17	16	16	16	16	16	16	16
	Mean	2.93	3.0^*	29.0	4.62	3.1^*	54.0	2.40	48.4	15.2	1.81
	SD	0.92	1.6–6.2^†	11.5	1.84	1.5–6.0^†	31.5	1.30	25.4	7.2	0.60
200 mg	n	19	19	19	18	18	18	18	18	18	18
	Mean	6.41	4.0^*	59.6	10.3	3.0^*	118	2.09	46.0	15.6	2.01
	SD	2.55	1.5–6.0^†	26.3	4.5	1.5–6.1^†	73	0.86	22.6	5.3	0.64

↵* Median.
↵† Min–Max range.
AR, accumulation ratio; AUC_{0–24 h}, area under the plasma concentration versus time curve from time 0 to 24 h; C_max, maximum observed drug concentration; CL_ss/F, oral clearance at steady state; t_1/2λz, apparent terminal half-life; t_max, time to reach C_max after dosing; V_z/F, apparent volume of distribution.