Author | Methods | Study population | Interventions | Outcomes |
Campbell, 198856 | Multicentre controlled study | 134 children of mean age 22 months and WHO-defined severe CAP in Gambia | Randomly assigned to oral co-trimoxazole for 5 days or procaine penicillin + benzylpenicillin one dose followed by oral ampicillin for 5 days |
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Addo-Yobo, 200457 | Multicentre randomised open-label equivalency trial | 1702 children aged 3–59 months with WHO-defined severe CAP in developing countries (Africa, Asia, and South America) | Randomly assigned to oral amoxicillin or IV penicillin G, both groups for 48 h followed by oral amoxicillin for another 5 days |
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Atkinson, 200758 | Multicentre randomised controlled non-blinded equivalency trial | 246 children aged ≥6 months with radiologically-confirmed CAP in England | Randomly assigned to oral amoxicillin for 7 days or IV benzylpenicillin, changed to oral amoxicillin after a median of six IV doses for a total course of antibiotics of 7 days | Treatment failure: 2.4% in the oral group and 5.8% in the IV group |
Hazir, 200859 | Multicentre randomised open-label equivalency trial | 2037 children aged 3–59 months with WHO-defined severe CAP in Pakistan | Randomly assigned to ambulatory group (oral amoxicillin for 5 days) or hospitalised group (IV ampicillin for 48 h followed by 3 days of oral amoxicillin) |
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IV, intravenous.