Study | Design | Fractures | Data source | COPD definition and patient characteristics | Type of ICS |
Gonnelli, 2010w27 | Cross-sectional | Vertebral | 57 Italian outpatient pulmonary centres January–December 2005, 3030 eligible patients | Age >50 years, referred by family physicians for COPD, FEV1/FVC <70%, with recent lateral CXR. Mean age 70 years, 58% males | BDP, BUD, FP, TRIAM |
Johannes, 2005w28 | Nested CC | Non-vertebral mainly (64%) upper or lower limb fractures | United Healthcare database 1997–2001. 609 cases/6323 controls | Adults aged ≥40 years with ICD-9 codes for COPD and asthma (we used data on patients with COPD only). Mean age 52 years, 30% of cases were male | FP, BDP, BUD, FLUNIS, TRIAM |
Lee, 2004w29 | Nested CC | Non-vertebral | VA patients; 1708 cases/6817 controls | New patients with COPD identified by ICD-9 coding. Mean age 63 years, 95% male, with 1.8 years follow-up | TRIAM, BDP, FLUNIS, FP |
McEvoy, 1998w30 | Cross-sectional | Vertebral | Minneapolis VA 176 users/136 non-users | Selection criteria: (1) male >50 years old; (2) primary diagnosis COPD; (3) FEV1/FVC ratio 70%; (4) smoking history ≥20 pack-years; and (5) >5 refills of a β-agonist inhaler within past year. Mean age 69 years | BDP, TRIAM |
Pujades-Rodríguez, 2007w31 | Nested CC | Any | UK Health Improvement Network database 1998–2005. 1235 cases/4598 controls | COPD diagnosis based on general practice records. Mean age 69 years, 40% males. Mean predicted FEV1 of 58%. Controls matched by sex and general practice | BDP, FP, BUD |
WEUSRTP1127 Miller, 2010w32 w34 | Nested CC Non-vertebral fracture | Non-vertebral | UK GPRD 2003–2006, 1523 cases/1876 controls | COPD diagnosis on computerised records. Age ≥45 years, 37% male. Controls matched on age, sex, general practice and duration in cohort prior to index date | Primary analysis FP, incomplete reporting BDP and BUD data |
WWE113669, 2008w33 | Nested CC | Non-vertebral | UK GPRD 1987–2000, 3105 cases/37 801 controls. | COPD diagnosis on computerised records. Age 50–85 years, 66% male. Controls matched on age, sex and general practice | FP, BUD, BDP |
BDP, beclomethasone; BUD, budesonide; CC, case–control; COPD, chronic obstructive pulmonary disease; CXR, chest x-ray; FEV1, forced expiratory volume in the first second of expiration; FLUNIS, flunisolide; FP, fluticasone, FVC, forced vital capacity; GPRD, General Practitioner Research Database; ICD, International Classification of Diseases; TRIAM, triamcinolone; VA, Veterans Affairs.