Table 4

Studies regarding impact of dosing intermittency on treatment efficacy in childhood tuberculosis

Authors, year of publicationMeasures of treatment efficacySource of study materialsStudy designMain findingsStrengthsWeaknessesRisk of bias
Menon et al, 201048CureIndia, South Africa, TurkeySystematic review and meta-analysis*By per protocol analysis, children treated intermittently were less likely to be cured than those treated daily (OR 0.27, 95% CI 0.14 to 0.51). By intention to treat analysis, findings were similar but statistically non-significant (OR 0.66, 95% CI 0.23 to 1.84). Twice-weekly TB treatment may be less efficacious than daily treatment in terms of cure rates for children.The study clearly addressed a focused question with good coverage on methodology and assessment of study quality. Literature search was sufficiently rigorous. Statistical tests showed no evidence of significant heterogeneity.Studies lacked uniformity in diagnosis and assessment of outcome.Low
  • * Articles identified by the literature search and included in systematic reviews identified by the current review are shown in appendix 3 in the online supplement.

  • TB, tuberculosis.