Table 2

Demographic data and clinical characteristics for patients with ALS with a tracheotomy performed during an acute episode and those with a non-urgent tracheotomy

Acute (n=21)Non-acute (n=17)p Value
Sex (M/F)8/138/90.578
Age (years)63.52±10.5566.88±6.920.267
BMI (kg/m2)27.17±3.2823.76±2.770.052
Spinal/bulbar onset11/108/90.744
Time from ALS onset to tracheotomy (months)42.26±47.9539.75±26.020.875
FVC (l)1.01±0.590.96±0.440.794
%FVC (%)38.47±19.7741.20±19.120.695
MIC (l)1.16±0.721.37±0.580.373
PCF (l/s)1.89±1.002.40±1.120.187
PCFMIC (l/s)2.15±1.222.70±1.150.206
PCFMI-E (l/s)2.77±0.873.51±1.170.058
PImax (cm H2O)−29.28±16.44−27.78±16.110.809
PEmax (cm H2O)42.57±27.8745.71±23.380.749
Home NIV prior to tracheotomy (Y/N)11/105/120.154
Home MAC prior to tracheotomy (Y/N)13/88/90.360
  • Data are expressed as means±SD for continuous variables and number for categorical variables.

  • ALS, amyotrophic lateral sclerosis; ALSFRS-R, revised amyotrophic lateral sclerosis functional rating scale; BMI, body mass index; FVC, forced vital capacity; %FVC, predicted FVC; MAC, mechanically assisted cough; MIC, maximum insufflation capacity; NBS, Norris bulbar subscore; NIV, non-invasive ventilation; PCF, peak cough flow; PCFMIC, manually assisted PCF; PCFMI-E, mechanically assisted PCF; PEmax, maximum expiratory pressure; PImax, maximum inspiratory pressure.