Outcome | Action plan group* (n=109) | Control group* (n=118) | Mean difference in change from baseline (95% CI) | Adjusted mean difference in change from baseline† (95% CI) | p Value | ||
Baseline (6 months) | Study period (6 months) | Baseline (6 months) | Study period (6 months) | ||||
Unscheduled physician visits | 1.2±1.7 | 0.9±1.5 | 1.1±1.5 | 0.9±1.2 | 0.12 (−0.38 to 0.63) | −0.12 (−0.38 to 0.41) | 0.93 |
Courses of antibiotics | 1.0±1.6 | 0.5±1.0 | 1.0±1.4 | 0.5±1.0 | 0.02 (−0.40 to 0.44) | 0.03 (−0.30 to 0.25) | 0.86 |
Courses of corticosteroids | 0.5±0.9 | 0.5±0.9 | 0.5±0.9 | 0.5±0.9 | −0.01 (−0.31 to 0.30) | −0.00 (−0.25 to −0.24) | 0.98 |
Physician-initiated increase in inhalation intake | 0.3±0.6 | 0.2±0.4 | 0.4±0.8 | 0.3±0.6 | 0.01 (−0.24 to 0.25) | 0.02 (−0.31 to 0.24) | 0.90 |
Emergency department visits for COPD exacerbation | 0.2±0.5 | 0.1±0.3 | 0.1±0.4 | 0.1±0.4 | 0.09 (−0.04 to 0.22) | −0.04 (−0.05 to 0.13) | 0.41 |
Hospitalisation for COPD exacerbation | 0.2±0.4 | 0.1±0.3 | 0.2±0.5 | 0.1±0.3 | 0.02 (−0.11 to 0.15) | −0.00 (−0.07 to 0.08) | 0.91 |
Number of patients with | |||||||
No hospital admission | 87 (80) | 102 (94) | 97 (82) | 109 (93) | 0.72 | ||
1 hospital admission | 21 (19) | 7 (6) | 18 (15) | 9 (8) | |||
>1 hospital admission | 1 (1) | 0 (0) | 3 (3) | 0 (0) | |||
Hospitalisation days for COPD exacerbation‡ | 12.3±8.3 | 6.6±2.8 | 10.6±5.2 | 11.9±9.8 | −5.36 (−12.15 to 1.43) | −4.15 (−16.68 to 1.38) | 0.09 |
↵* Unless otherwise indicated, data are mean±SD or n (%).
↵† Difference in change from baseline adjusted for the baseline value of the parameter and centre; corresponding 95% CIs and p values are calculated using ANCOVA.
↵‡ Number of days for patients with at least one exacerbation-related hospital admission.
COPD, chronic obstructive pulmonary disease.