Table 2

Exacerbation-related outcomes according to intervention group

Outcome	Action plan group (n=103)	Control group (n=113)	Treatment difference (95% CI)	p Value
Total patient-years	46.65	52.24
Mean follow-up per patient (years)	0.45±0.11	0.46±0.09	−0.01 (−0.04 to 0.02)	0.50^*
Number of exacerbations	128	136
Weighted exacerbation rate (patient-year)	2.80	2.60	1.07 (0.76 to 1.25)	0.73^†
Number of patients with
0 exacerbation	48 (47)	57 (50)		0.77^‡
1 exacerbation	24 (23)	22 (20)
>1 exacerbations	31 (30)	34 (30)
Exacerbation days for
All patients	19.4±26.8	21.8±32.3	−2.4 (−10.4 to 5.6)	0.56^*
Patients with ≥1 exacerbation	35.1±27.6	44.1±33.6	−9.0 (−20.5 to 2.6)	0.13^*
Anthonisen classification^§
3 major symptoms	28 (22)	41 (30)		0.03^‡
2 major symptoms	33 (26)	48 (35)
1 major + ≥1 minor symptom	67 (52)	47 (35)
Symptom count (points)^§	77.2±65.0	85.1±90.1	−8.0 (−12.8 to 28.9)	0.45^*
Reported exacerbations^§	37 (29)	46 (34)		0.55^‡
Contact delay (days)^§	4.5±5.9	7.5±8.8	−2.9 (−3.5 to 2.4)	<0.001^*

Unless otherwise indicated, data are mean±SD, n (%) or median (IQR).
↵* Student t test.
↵† Rate ratio calculated using Poisson regression.
↵‡ χ² test.
↵§ Exacerbations at onset and exacerbations from which the patient had not recovered at follow-up were not included in the analysis.