Prostanoid EP receptor agonist and antagonist affinities
| Ligand | Action | Affinity | Units | References | |
| Agonist | |||||
| EP1 | ONO-D1-004 | Full agonist | 6.8 (mouse) | pKi | 34 |
| EP2 | AH 13205 | Full agonist | 6 (human) | pKi | 35 |
| ONO-AE1-259 | Full agonist | 8.5 (mouse) | pKi | 34 | |
| Butaprost | Full agonist | 5.9–7.0 (human) | pKi | 24 | |
| Misoprostol | Full agonist | 5.0 (human) | pKi | 24 | |
| ONO-AE-248 | Full agonist | 5.4 (mouse) | pKi | 34 | |
| ONO-AE1-329 | Full agonist | 5.7 (mouse) | pKi | 34 | |
| EP3 | Misoprostol | Full agonist | 6.5 (human) | pKi | 24 |
| Butaprost | Full agonist | 5.8 (human) | pKi | 24 | |
| ONO-AE-248 | Full agonist | 8.1 (mouse) | pKi | 34 | |
| EP4 | ONO-AE1-329 | Full agonist | 8.0 (mouse) | pKi | 24 |
| Misoprostol | Full agonist | 5.3 (human) | pKi | 24 | |
| Butaprost | Full agonist | 4.7 (human) | pKi | 24 | |
| Antagonist | |||||
| EP1 | AH6809 | Antagonist | 5.9 (human) | pKi | 24 |
| EP2 | AH6809 | Antagonist | 5.9 (human) | pKi | 24 |
| EP4 | AH23848 | Antagonist | 4.9–5.6 (human) | pKi | 24 |
| ONO-AE3-208 | Antagonist | 8.9 (mouse) | pKi | 26 | |
| GW627568 | Antagonist | 7.0–7.1 (human) | pKi | 25 | |