Table 2

Haematological and biochemical indices in patients with chronic obstructive pulmonary disease (COPD) and controls

Study 1Study 2
ControlsCOPDp ValueStableExacerbationp Value
Measures of platelet activation
 Platelet-monocyte aggregates, %19.5 (4.0)25.3 (8.3)0.0125.5 (6.4)32.0 (11.0)0.03
 P-selectin expression, %1.1 (0.8)1.6 (1.2)0.160.8 (1.2)1.4 (2.1)0.40
 Soluble P-selectin, ng/ml53.0 (22.2)56.5 (20.3)0.6553.5 (17.8)61.5 (20.8)0.56
Haematological indices
 Leucocytes, cells, ×109/l5.3 (1.3)7.0 (1.4)0.237.9 (1.6)14.8 (3.2)<0.001
 Monocytes, ×109/l0.5 (0.2)0.6 (0.2)0.0010.7 (0.3)1.0 (0.3)0.001
 Haemoglobin, g/l139 (11)141 (13)0.03136 (9)138 (12)0.40
 Haematocrit0.4 (0.03)0.4 (0.03)0.0040.4 (0.02)0.4 (0.04)0.41
 Platelets, ×109/l196 (31)262 (68)0.001290 (54)333 (127)0.09
 D-dimer, ng/ml341 (202)373 (137)0.63
 Fibrinogen, mg/dl2.7 (0.5)2.8 (0.5)0.49
Biochemistry
 Total cholesterol, mmol/l4.9 (0.9)5.5 (0.7)0.035.4 (1.4)
 Glucose, mmol/l5.2 (0.6)5.1 (0.6)0.715.5 (1.7)
 C-reactive protein, mg/l*1.0 (0.5–3.2)2.1 (1.3–5.4)0.032.8 (1.6–8.2)41 (4–103)0.01
 Arterial oxygenation, kPa12.3 (1.6)10.5 (1.7)0.004
  • Values are mean (SD) unless indicated otherwise.

  • p Values calculated using independent samples t test in study 1 and paired t tests in study 2. C-reactive protein was log-transformed for analysis.

  • * Median (IQR).