Table 2

Genes showing significantly different expression according to GOLD stage

Gene nameGene IDp ValueFold changeFunction
ZBTB16244697_at<0.00013.31Transcription factor
TPST1204140_at<0.00012.96Peptidyl-tyrosine sulfation /// inflammatory response
TANK237609_at<0.00012.70Signal transduction with TRAF
DAAM2212793_at<0.00012.45Cellular component organisation and biogenesis /// actin cytoskeleton organisation and biogenesis
ZNF165206683_at<0.00012.41Regulation of transcription
UPB1220507_s_at<0.00012.38Nitrogen compound metabolic process
SYNJ2234153_at<0.00012.37Phosphatase enzyme
KIF27240547_at<0.00012.37Microtubule associated
IL1RL1242809_at<0.00012.35Signal transduction /// innate immune response
CCNA1205899_at<0.00012.33Cell cycle
GREB1205862_at<0.0001−2.83Oestrogen responsive pathways
SCD211708_s_at<0.0001−2.90Lipid metabolic process
IGFBP2202718_at<0.0001−2.94Regulation of cell growth
PRSS21220051_at<0.0001−3.01Proteolysis
ADPN233030_at<0.0001−3.02Metabolic process /// lipid catabolic process
VGL-3227399_at<0.0001−3.04Regulation of transcription
TPD52L1203786_s_at<0.0001−3.05G2/M transition of mitotic cell cycle /// DNA fragmentation during apoptosis
CADPS2219572_at<0.0001−3.09Transport /// exocytosis /// protein transport
FABP4235978_at<0.0001−3.18Cytokine production /// negative regulation of protein kinase activity
CPE201116_s_at<0.0001−3.40Protein modification process /// proteolysis

  • The 10 most highly up and down regulated genes are shown. Function was obtained by mapping to GO Processes or manual literature mapping. Positive fold change values indicate increase in GOLD stage 3/4 compared to GOLD stage 2.