Baseline participant characteristics and 11478G→A genotype in the ELSA (n=1805) and Whitehall II (n=2733) studies
| GG | GA/AA | p Value | |
| ELSA (wave 0, 2001) | |||
| Men n (%) | 724 (46.5%) | 112 (45.0%) | 0.46 |
| Age (years) | 61.6 (61.4 to 62.3) | 61.5 (60.4 to 62.6) | 0.74 |
| FEV1 (litres) | 2.56 (2.52 to 2.60) | 2.56 (2.47 to 2.65) | 0.94 |
| FEV1 (% predicted) | 89 (87 to 90) | 90 (87 to 92) | 0.48 |
| FVC (litres) | 3.26 (3.21 to 3.31) | 3.26 (3.15 to 3.38) | 0.97 |
| Smoking (pack-years)* | 19.3 (18.4 to 20.3) | 18.6 (16.2 to 21.0) | 0.58 |
| BMI (kg m−2) | 27.7 (27.4 to 27.9) | 27.3 (26.6 to 27.9) | 0.28 |
| Current smoker % | 15.0 | 15.8 | 0.58 |
| Whitehall II (phase 7, 2002–2004) | |||
| Men n (%) | 1726 (86.6) | 648 (87.7) | 0.44 |
| Age (years) | 61.3 (60.9 to 61.8) | 60.9 (60.7 to 61.1) | 0.10 |
| FEV1 (litres) | 2.94 (2.86 to 3.01) | 2.92 (2.90 to 2.95) | 0.59 |
| FEV1 (% predicted) | 77 (76 to 78) | 77 (77 to 77) | 0.93 |
| FVC (litres) | 3.93 (3.85 to 4.02) | 3.91 (3.87 to 3.94) | 0.57 |
| Smoking (pack-years) | 6.72 (6.01 to 7.42) | 6.30 (6.02 to 6.58) | 0.28 |
| BMI (kg m−2) | 26.8 (26.4 to 27.1) | 26.8 (26.6 to 26.9) | 0.96 |
| Current smoker % | 13.3 | 12.2 | 0.68 |
Data are expressed as means (95% CI) adjusted for age in linear regression for continuous variables and number (percentage) for categorical variables. Analyses are limited to those participants with lung function data from two time points.
↵* Calculated in ever smokers.
BMI, body mass index; ELSA, English Longitudinal Study of Ageing; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.