Table 3

Estimates of lung and systemic inflammation in association with proximity of home to major roads

Change in inflammatory markersEstimate (95% CI)p-Value
Lung inflammation (bronchoalveolar lavage)
Total cell count (×106/ml)−0.035 (−0.1091 to 0.0386)0.350
Neutrophils (%)−0.119 (−0.2264 to −0.0112)0.031
Interleukin-6 (pg/ml)−0.164 (−0.3376 to 0.0092)0.064
Interleukin-8 (pg/ml)−0.065 (−0.1702 to 0.0409)0.230
Systemic inflammation (plasma)
C-reactive protein (mg/litre)−0.107 (−0.1935 to −0.0197)0.017
  • Estimates express change (95% CI) in the dependent variable for a 10-fold increase in distance between home and a major road. The analysis included 943 observations in 207 patients; median number of measurements per patient is five (5th–95th percentile: 1–8). Differences based on mixed model, adjusted for clustering and other covariates, as in previous models, including sex, age, type of transplantation (single or double lung transplantation), infection with cytomegalovirus (CMV) and non-CMV infections, acute rejections, a factor reflecting time trend and social economic status. Interaction term between time after transplantation and distance to a major road was not significant for any of the studied markers (p≥0.52).