Table 3

Effects of adaptive servoventilation (ASV) in patients witch congestive heart failure and complex sleep apnoea (n=27)

Baseline (at ASV introduction)Last follow-up visit under ASV therapy (14±4 months)Significance (p Value)
Sleep study results
 AHI, /h34.0±14.78.1±9.6<0.0001
 AI, /h18.3±13.42.0±3.90.008
 cAI, /h17.4±12.50.77±1.79<0.0001
 Average oxygen saturation, %93.2±1.894.3±1.50.37
 Lowest oxygen saturation, %81.9±5.387.3±4.40.0004
 Mean desaturation, %5.6±2.04.6±1.80.26
 Longest apnoea period, s40.4±16.321.2±19.8<0.0001
 Longest hyponea period, s43.9±16.641.6±22.70.92
NYHA class2.7±0.71.9±0.9<0.0001
Systolic blood pressure, mm Hg120.1±22.4117.1±21.70.52
Diastolic blood pressure, mm Hg71.1±14.073.2±15.40.53
Heart rate72.5±13.172.0±13.60.52
Blood gas analysis
 pco2, mm Hg37.0±4.037.8±4.10.21
 po2, mm Hg77.6±11.680.8±11.80.38
 LVEF (%)31.1±7.134.8±12.10.04
 LVEDD, mm68.8±7.465.3±14.50.18
 LAD, mm49.5±8.551.3±9.60.34
Cardiopulmonary exercise testing and six-minute walk
 Duration, min7.4±2.48.3±2.10.10
 Maximum workload, W90.6±32.597.6±29.80.15
 Vo2-AT, ml/min/kg12.7±3.614.3±3.90.03
 Vo2 peak, ml/min/kg14.8±4.316.5±5.20.04
 Vo2 predicted, %61.7±18.271.7±21.10.02
 VE/Vco2 slope33.7±5.331.8±5.20.08
 Six-minute walk test, m371±82421±960.09
Laboratory measurement
 NT-proBNP, pg/ml2518±33402118±16670.01
 Hb, /ml14.0±1.314.0±1.30.42
 Sodium, μg/l139.6±7.9139.4±3.60.23
 Creatinine, μg/l1.3±0.41.4±0.50.33
 CRP, ng/ml0.8±0.80.6±0.70.27
HCVR, l/min/mm Hg4.60±3.663.11±2.30.03
  • AHI, apnoea– hypopnoea index; AI, apnoea index; BE, base excess; BMI, body mass index; Hb, haemoglobin; cAI, central apnoea index; HCVR, hyperoxic, hypercapnic ventilatory response; LAD, left atrium dimension; LVEDD, left ventricular end-diastolic dimension; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-brain natriuretic peptide; NYHA, New York Heart Association; pco2, partial pressure of CO2; po2, partial pressure of O2; sPAP, systolic pulmonary artery pressure; VE/Vco2 slope; the relationship between minute ventilation and the rate of CO2 elimination; Vo2, oxygen consumption; Vo2-AT, oxygen consumption at the individual aerobic–anaerobic threshold.