Table 4

Univariable and multivariable analysis, by generalised estimating equation models, for development of acute respiratory distress syndrome over the course of mechanical ventilation

OR95% CIp-ValueOR95% CIp-Value
Age, per year0.990.98 to 1.000.861
 Male1 (reference)
 Female0.900.65 to 1.260.550
Body mass index by category
 Underweight1 (reference)1 (reference)
 Normal1.330.57 to 3.100.5071.620.58 to 4.500.352
 Overweight2.040.86 to 4.840.1062.230.80 to 6.220.126
 Obese/severely obese2.591.11 to 6.060.0283.071.07 to 8.840.037
SAPS II, per point1.000.99 to 1.010.493
Reason of mechanical ventilation
 Neurological disease1 (reference)1 (reference)
 Chronic pulmonary disease0.940.31 to 2.850.9160.820.22 to 3.070.773
 Acute respiratory failure without a priori risk for ARDS*1.530.87 to 2.700.1361.100.60 to 1.990.752
 Trauma2.301.17 to 4.530.0211.370.69 to 2.680.263
 Sepsis2.591.16 to 5.800.0161.850.81 to 4.220.144
 Pneumonia3.321.72 to 6.40<0.0012.151.00 to 4.650.050
 Aspiration4.982.22 to 11.20<0.0013.481.32 to 9.170.012
Ventilator associated pneumonia1.910.92 to 3.990.0831.130.49 to 2.620.765
Sepsis over the course of mechanical ventilation
 No1 (reference)1 (reference)
 Pulmonary2.581.37 to 4.840.0031.830.88 to 3.800.105
 Extrapulmonary2.941.49 to 5.780.0022.711.37 to 5.380.004
Shock over the course of mechanical ventilation3.282.26 to 4.76<0.0012.501.62 to 3.87<0.001
Tidal volume (ml/kg predicted body weight), per unit1.020.97 to 1.070.469
PEEP, per cmH2O1.311.22 to 1.39<0.0011.041.01 to 1.070.006
  • * This variable includes: Postoperative acute respiratory failure, congestive heart failure, cardiac arrest.