Table 4

Previous studies reporting lung function prior to lower respiratory tract infections (LRTIs) in infancy

ReferencesSample sizeGA at birthPMA at assessment (weeks)Viral identificationLung function test results
Young et al6253Term45RSV (n=2)Bronchiolitis (n=10)Control (n=236)p Value
Tme/TE (%)30.4 (3.5)33.7 (0.10)NS
Rrs (cm H2O/l/s)60 (5)56 (10)NS
Crs (ml/cm H2O/kg)1.4 (0.1)1.4 (0.03)NS
Martinez et al7124Term48Virology not reportedLRTI with wheeze (n=24)No LRTI (n=88)p Value
Tme/TE (%)25.4 (6.9)31.2 (9.2)0.01
Conductance (l/s/cm H2O)0.028 (0.006)0.035 (0.009)0.04
FRC He (ml)97.1 (20.8)103.2 (16.7)0.63
Vmax FRC (ml/s)118.6 (51.2)131.2 (47.9)0.50
Broughton et al9392836RSV (n=15)RSV LRTI (n=15)No RSV LRTI (n=24)p Value
Rrs (cm H2O/l/s)126 (62)89 (28)0.01
Crs (ml/cm H2O/kg)1.0 (0.5)1.0 (0.5)0.82
FRC He (ml/kg)22 (4)22 (3)0.94
  • Data are demonstrated as mean (SD).

  • Crs, compliance of the respiratory system; FRC, functional residual capacity; GA, gestational age; He, helium dilution; NS, non-significant; Rrs, resistance of the respiratory system; RSV, respiratory syncitial virus: Tme/TE, the time to maximal expiratory flow as a proportion of total expiratory time.