Subject | Baseline | 6 months | 12 months | Outcomes | Baseline | 6 months | 12 months | Outcomes | Progression |
FVC | FVC | FVC | By period† | O2 Sat | O2 Sat | O2 Sat | By period† | On HRCT | |
1 | 49.80 | 52.50 | 52.20 | S–S–S | 75 | 75 | 75 | S–S–S | None |
3 | 36.70 | 38.50 | 41.80 | S–S–S | 85 | 78 | 82 | W–I–S | None |
4 | 73.40 | 70.30 | 72.70 | S–S–S | 99 | 96 | 97 | S–S–S | None |
5 | 59.00 | 59.80 | 51.00 | S–W–S | 61 | 63 | 60 | I–S–S | Slight§ |
8 | 72.60 | 69.10 | 67.40 | S–S–S | 91 | 93 | 92 | I–S–S | Slight |
11 | 47.30 | 37.70 | 37.40 | W–S–W | ‡ | ‡ | |||
12 | 66.00 | 78.80 | 72.30 | I–S–S | 83 | 83 | 82 | S–S–S | None |
15 | 54.00 | 63.40 | 56.70 | I–W–S | 80 | 74 | 65 | W–W–W | Slight |
16 | 43.10 | 40.00 | 40.00 | S–S–S | 67 | 82 | 77 | I–W–I | Slight |
18 | 68.30 | 62.20 | 59.70 | S–S–S | 83 | 82 | 73 | S–W–W | None |
19 | 63.90 | 59.60 | 48.10 | S–W–W | 86 | 91 | 86 | I–W–S | None |
20 | 49.80 | 49.50 | 45.70 | S–S–S | 85 | 81 | 83 | W–S–S | None |
↵* Stable defined as a value less than a ±10% change for FVC and less than a ±4% point change for O2 saturation post-exercise. Values at the end of the first period were used as baseline for the second period. One-year outcomes based on ±changes of <19 and 8% for FVC and O2 saturation, respectively, comparing 12 month values with baseline.
↵† Outcomes are indicated by: I=improved, S=stable and W=worse for the first 6 month period, the second 6 month period and 1 year in that order.
↵‡ Subject unable to perform 6 min walk due to physical disability and baseline HRCT lost.
↵§ Slight progression reflects a change due to a very minimal increase in disease or a technical factor of lung image when comparing 12 month scan with baseline scan.
FVC, forced vital capacity; HRCT, high resolution CT.