Table 4

Factors associated with adherence to the action plan:* univariable and multivariable analyses on 217 exacerbations

Categories or unitsOR95% CI
Univariable analysis
 Influenza vaccinationYes vs no4.831.74 to 13.37
 Cardiac diseaseYes vs no2.441.08 to 5.52
 Exacerbation intervention plan prior to studyYes vs no1.630.75 to 3.54
 Post-BD FEV1Each % predicted0.980.96 to 1.00
 AgeEach year0.980.94 to 1.02
 SexFemale vs male1.280.65 to 2.52
 Exacerbation sequenceEach exacerbation1.110.84 to 1.46
 Number of exacerbation symptoms3 vs 2 symptoms1.450.73 to 2.87
 ER COPD visit prior to studyEach visit1.110.85 to 1.44
 Contacting the case managerYes vs no1.190.6 to 2.38
 Depressive symptomsYes vs no0.950.85 to 1.07
 Pulmonary rehabilitation in RCT§Home vs hospital1.250.63 to 2.48
Multivariable analyses
 Influenza vaccinationYes vs no4.821.71 to 13.54
 Cardiac diseaseYes vs no3.051.26 to 7.39
 AgeEach year0.960.92 to 1.00
 Post-BD FEV1Each % predicted0.980.95 to 1.00
Random effectsEstimate95% CI
 Subject0.47−0.32 to 1.26
 Study centre0.51−0.33 to 1.35
  • * Adherence to the action plan was defined as the initiation of both prednisone and antibiotics within 3 days of exacerbation onset. All other actions were defined as non-adherence.

  • Cardiac disease includes chronic heart failure, angina pectoris, myocardial infarction and arrhythmia.

  • Depressive symptoms were measured with the 15-item Geriatric Depression Scale (GDS). Sum scores (range 0–15) ≥6 points are suggestive for depression.

  • § Canadian pulmonary rehabilitation trial ( identifier: NCT00169897).

  • After backward elimination with removal of variables with p>0.05.

  • Post-BD FEV1, post-bronchodilator forced expiratory volume in 1 s.