High pepsin (n=19) | Low pepsin (n=12) | p Value | |
Mean age (years) | 10.73 | 10.07 | 0.79 |
Gender (M/F) | 13/6 | 7/5 | 0.53 |
Neutrophils (×106/ml BAL) | 5.52 | 2.61 | 0.15 |
BMI z score | −0.94 | −0.7 | 0.66 |
FEV1 (% predicted) | 63 | 68.4 | 0.73 |
BAL NE activity (nM) | 56 | 37 | 0.29 |
PPI use | 6/19 (32%) | 3/12 (25%) | 0.69 |
pH probe performed | 5/19 (26%) | 1/12 (8%) | 0.21 |
Positive pH probe | 5/5 (100%) | 1/1 (100%) | NS |
Chronic P aeruginosa colonisation | 6/19 (32%) | 3/12 (25%) | 0.69 |
Differences in individual means were calculated by Student t test or Mann–Whitney U test for continuous data, and χ2 test for categorical data.
BAL, bronchoalveolar lavage; BMI, body mass index; FEV1, forced expiratory volume in 1 s; NE, neutrophil elastase; NS, not significant; PPI, proton pump inhibitor.