Characteristics of the subjects with AATD and COPD
| Characteristic | AATD (n=471) | AATD with COPD (n=364) | AATD without COPD (n=107) | AATD subset (n=60) | COPD (n=140) |
| Age | 50.33 (10.35) | 51.75 (9.33) | 43.46 (36.37–56.36) | 49.71 (9.88) | 68.82 (0.93) |
| Male gender | 281 (59.70) | 233 (64.00) | 57 (53.27) | 37 (61.67) | 79 (56.61) |
| Pack-years smoked | 15.00 (2.25–25.0) | 18.00 (9.00–26.81) | 0 (0–10.38) | 21.00 (13.65–27.25) | 43.50 (31.72–58.00) |
| FEV1 % predicted | 45.30 (28.45–72.33) | 36.70 (25.86–52.74) | 104.91 (18.63) | 35.66 (22.38–56.41) | 43.43 (15.84) |
| FEV1/FVC | 39.00 (29.00–56.00) | 34.00 (27.00–44.75) | 80.00 (71.00–85.50) | 34.00 (26.75–48.25) | 36.00 (28.72–51.00) |
| COPD | 364 (78.62) | 364 (100) | 0 | 49 (81.67) | 140 (100) |
| Bronchiectasis* | 111 (25.20) | 88 (24.20) | 22 (25.00) | 20 (33.33) | 8 (18.6) |
| Airway bacterial colonisation* | 52 (69.31) | 45 (67.16) | 6 (85.71) | 26 (68.41) | – |
| Exacerbations per year | 1.00 (0–2) | 1.00 (0–2) | 1.00 (0–2) | 1.00 (1–2) | 2.00 (1–4) |
The table shows the mean (SD) or median (IQR) for all quantitative outcomes, and number (%) for the qualitative outcomes, these being gender, COPD, emphysema, bronchiectasis and airway bacterial colonisation. Mean (SD) is shown where data are normally distributed, and median (IQR) where they are non-normal.
↵* Percentages shown as a proportion of scans and sputum obtained, respectively.
AATD, α1-antitrypsin deficiency; COPD, chronic obstructive pulmonary disease; FEV1, forced expiratory volume in 1 s; FVC, forced vital capacity.