Ventilatory pattern at maximal exercise in patients with pulmonary fibrosis, cystic fibrosis, chronic obstructive pulmonary disease (COPD), healthy control subjects and transplanted patients
| Pulmonary fibrosis (PF) | Cystic fibrosis (CF) | COPD | Healthy controls (HC) | Transplanted (T) | ||||||
| n | 9 | 9 | 21 | 10 | 16 | |||||
| VT (litres) | 0.75±0.10 | *** vs HC, T; * vs COPD | 0.79±0.07 | *** vs HC, T; * vs COPD | 1.25±0.08 | *** vs HC | 2.60±0.33 | 2.30±0.22 | ||
| ΔVRC (%VT) | 41.3±7.8 | 40.0±4.7 | 50.0±3.2 | 47.6±3.9 | 41.1±3.3 | |||||
| ΔVAB (%VT) | 58.7±7.8 | 60.0±4.7 | 50.0±3.2 | 52.4±3.9 | 58.9±3.3 | |||||
| TTOT (s) | 1.45±0.24 | *** vs COPD | 1.86±0.13 | *** vs COPD | 3.16±0.23 | *** vs T; ** vs HC | 2.24±0.24 | 2.16±0.08 | ||
| TI (s) | 0.62±0.10 | *** vs COPD; ** vs HC; * vs T | 0.81±0.07 | * vs HC | 1.03±0.06 | 1.09±0.11 | 0.93±0.04 | |||
| TE (s) | 0.83±0.15 | *** vs COPD | 1.05±0.06 | *** vs COPD | 2.12±0.18 | *** vs T; ** vs HC | 1.15±0.13 | 1.23±0.06 | ||
| Duty cycle (TI/TTOT, %) | 43.8±1.9 | * vs HC | 43.5±0.9 | * vs HC | 33.9±1.1 | *** vs PF, CF, HC, T | 49.0±1.0 | ** vs T | 43.6±1.03 | |
| Breath. frequency (/min) | 49.4±6.1 | *** vs CF, COPD, HC, T | 33.9±2.3 | *** vs COPD | 21.3±1.6 | ** vs HC, T | 30.0±3.2 | 28.7±1.02 | ||
| Minute ventilation (l/min) | 34.8±5.4 | *** vs HC, T | 26.8±2.7 | *** vs HC, T | 24.9±1.4 | *** vs HC,T | 73.1±8.9 | 62.3±5.8 | ||
| Mean inspiratory flow (VT/TI, l/s) | 1.34±0.17 | *** vs HC, T | 1.04±0.12 | *** vs HC, T | 1.25±0.06 | *** vs HC, T | 2.50±0.29 | 2.50±0.20 | ||
| Borg breath | 4.2±1.2 | (n=8) | 5.7±1.3 | (n=7) | 5.8±0.6 | (n=13) | 4.0±0.4 | (n=10) | 7.13±0.9 | (n=8) |
| Borg leg | 2.5±1.2 | (n=8) | 5.1±1.3 | (n=7) | 5.7±0.8 | (n=13) | 5.7±0.6 | (n=10) | 7.75±0.7 | (n=8) |
*p<0.05, **p<0.01, ***p<0.001.
TE, expiratory time; TI, inspiratory time; TTOT, total respiratory cycle time;.VT, tidal volume; ΔVAB, percentage contribution of abdomen to tidal volume; ΔVRC, percentage contribution of rib cage to tidal volume.