Table 7

Areas under the curve (AUC) for receiver operator characteristic analyses in which measurements of FEV1 at baseline, FEV1 at loss of control (LOC) or 28 days after steroid withdrawal, change in FEV1 with bronchodilator at baseline, AHR as measured by PD15HS and by PC20AMP and Feno were used as predictors

FEV1 (baseline)0.3080.6130.2540.3050.8490.387
FEV1 (LOC)0.4260.8180.4110.3150.8650.379
BD response0.4350.6090.5490.4290.6160.470
  • The outcomes were: change in airway hyper-responsiveness as measured by PC20AMP (ΔPC20AMP), change in FEV1 (ΔFEV1) and change in ACQ (ΔACQ) following 28+ days of inhaled fluticasone treatment in 60 patients with eosinophilic asthma (EA) (49 for PC20AMP) and 28 patients with non-eosinophilic asthma (NEA). An AUC of >0.7 is considered significant.

  • ACQ, Asthma Control Questionnaire; BD response, bronchodilator response; FEV1, forced expiratory volume in 1 s; Feno, fraction of exhaled nitric oxide; PC20AMP, provocation concentration of adenosine monophosphate causing a 20% fall in FEV1; PD15HS, provocation dose of hypertonic saline causing a 15% fall in FEV1.