Association between annual average exposure to air pollution at the birth address and asthma symptoms from age 2 up to 8 years of age, stratified by different genotypes of TLR2 single nucleotide polymorphisms (SNPs)
| TLR2 SNP | Adjusted OR* (95% CI) | p Values interaction† | ||
| rs4696480 | TT | TA | AA | TA/AA |
| PM2.5 | 1.10 (0.73 to 1.66) | 1.32 (0.95 to 1.83) | 0.96 (0.53 to 1.72) | 0.50/0.69 |
| Soot | 1.14 (0.79 to 1.65) | 1.18 (0.88 to 1.57) | 0.97 (0.56 to 1.69) | 0.90/0.63 |
| NO2 | 1.18 (0.84 to 1.66) | 1.09 (0.83 to 1.42) | 0.94 (0.57 to 1.54) | 0.72/0.45 |
| rs1898830 | AA | AG | GG | AG/GG |
| PM2.5 | 1.09 (0.70 to 1.69) | 1.16 (0.84 to 1.61) | 1.46 (0.80 to 2.65) | 0.81/0.44 |
| Soot | 1.02 (0.68 to 1.53) | 1.17 (0.87 to 1.58) | 1.26 (0.75 to 2.10) | 0.58/0.53 |
| NO2 | 1.01 (0.69 to 1.46) | 1.11 (0.85 to 1.46) | 1.20 (0.74 to 1.95) | 0.67/0.57 |
| rs3804099 | TT | TC | CC | TC / CC |
| PM2.5 | 1.24 (0.84 to 1.83) | 1.02 (0.74 to 1.41) | 1.26 (0.62 to 2.56) | 0.45/0.96 |
| Soot | 1.25 (0.87 to 1.79) | 1.00 (0.75 to 1.33) | 1.18 (0.62 to 2.25) | 0.33/0.88 |
| NO2 | 1.19 (0.86 to 1.65) | 0.96 (0.73 to 1.25) | 1.14 (0.62 to 2.10) | 0.30/0.91 |
| rs3804100 | TT | TC or CC | ||
| PM2.5 | 1.16 (0.90 to 1.50) | 0.92 (0.48 to 1.75) | 0.50 | |
| Soot | 1.14 (0.90 to 1.44) | 0.86 (0.49 to 1.54) | 0.38 | |
| NO2 | 1.09 (0.88 to 1.36) | 0.81 (0.49 to 1.36) | 0.29 | |
↵* ORs represent the factor by which the odds of asthma changes with an interquartile range increase in annual average pollutant concentration at birth address adjusted for confounders within each genotype group.
↵† p Values of interaction represent p values of the differences in ORs between the specific genotype group and the common allele homozygote group.