Table 4

Association between annual average exposure to air pollution at the birth address and asthma symptoms from age 2 up to 8 years of age, stratified by different genotypes of TLR2 single nucleotide polymorphisms (SNPs)

TLR2 SNPAdjusted OR* (95% CI)p Values
interaction
rs4696480TTTAAATA/AA
 PM2.51.10 (0.73 to 1.66)1.32 (0.95 to 1.83)0.96 (0.53 to 1.72)0.50/0.69
 Soot1.14 (0.79 to 1.65)1.18 (0.88 to 1.57)0.97 (0.56 to 1.69)0.90/0.63
 NO21.18 (0.84 to 1.66)1.09 (0.83 to 1.42)0.94 (0.57 to 1.54)0.72/0.45
rs1898830AAAGGGAG/GG
 PM2.51.09 (0.70 to 1.69)1.16 (0.84 to 1.61)1.46 (0.80 to 2.65)0.81/0.44
 Soot1.02 (0.68 to 1.53)1.17 (0.87 to 1.58)1.26 (0.75 to 2.10)0.58/0.53
 NO21.01 (0.69 to 1.46)1.11 (0.85 to 1.46)1.20 (0.74 to 1.95)0.67/0.57
rs3804099TTTCCCTC / CC
 PM2.51.24 (0.84 to 1.83)1.02 (0.74 to 1.41)1.26 (0.62 to 2.56)0.45/0.96
 Soot1.25 (0.87 to 1.79)1.00 (0.75 to 1.33)1.18 (0.62 to 2.25)0.33/0.88
 NO21.19 (0.86 to 1.65)0.96 (0.73 to 1.25)1.14 (0.62 to 2.10)0.30/0.91
rs3804100TTTC or CC
 PM2.51.16 (0.90 to 1.50)0.92 (0.48 to 1.75)0.50
 Soot1.14 (0.90 to 1.44)0.86 (0.49 to 1.54)0.38
 NO21.09 (0.88 to 1.36)0.81 (0.49 to 1.36)0.29
  • * ORs represent the factor by which the odds of asthma changes with an interquartile range increase in annual average pollutant concentration at birth address adjusted for confounders within each genotype group.

  • p Values of interaction represent p values of the differences in ORs between the specific genotype group and the common allele homozygote group.