TLR2 SNP | Adjusted OR* (95% CI) | p Values interaction† | ||
rs4696480 | TT | TA | AA | TA/AA |
PM2.5 | 0.94 (0.58 to 1.53) | 1.96 (1.22 to 3.14)** | 1.69 (0.53 to 5.35) | 0.04/0.36 |
Soot | 0.97 (0.63 to 1.50) | 1.63 (1.06 to 2.51)* | 1.68 (0.58 to 4.86) | 0.10/0.35 |
NO2 | 1.00 (0.66 to 1.51) | 1.46 (1.01 to 2.11)* | 1.51 (0.59 to 3.85) | 0.18/0.43 |
rs1898830 | AA | AG | GG | AG/GG |
PM2.5 | 2.24 (0.98 to 5.15) | 1.44 (0.92 to 2.25) | 0.72 (0.33 to 1.53) | 0.36/0.05 |
Soot | 1.87 (0.88 to 3.97) | 1.43 (0.96 to 2.12) | 0.67 (0.36 to 1.27) | 0.53/0.04 |
NO2 | 1.67 (0.87 to 3.21) | 1.32 (0.91 to 1.92) | 0.73 (0.41 to 1.29) | 0.53/0.06 |
rs3804099 | TT | TC | CC | TC/CC |
PM2.5 | 1.06 (0.64 to 1.75) | 1.40 (0.87 to 2.28) | 2.16 (0.65 to 7.21) | 0.42/0.28 |
Soot | 1.13 (0.72 to 1.79) | 1.33 (0.87 to 2.02) | 1.76 (0.62 to 4.98) | 0.61/0.44 |
NO2 | 1.17 (0.77 to 1.76) | 1.16 (0.78 to 1.72) | 1.71 (0.66 to 4.46) | 0.99/0.46 |
rs3804100 | TT | TC or CC | ||
PM2.5 | 1.32 (0.89 to 1.96) | 1.24 (0.44 to 3.46) | 0.91 | |
Soot | 1.34 (0.92 to 1.93) | 0.77 (0.33 to 1.81) | 0.25 | |
NO2 | 1.26 (0.89 to 1.78) | 0.78 (0.38 to 1.63) | 0.24 |
Bold values are significant: *p<0.05; **p<0.01.
↵* ORs represent the factor by which the odds of asthma changes with an interquartile range increase in annual average pollutant concentration at birth address adjusted for confounders within each genotype group.
↵† p Values of interaction represent p values of the differences in ORs between the specific genotype group and the common allele homozygote group.