Mean 6MWD for the subgroup alive and able to complete the 6MWT at all three time points stratified by the SGRQ and FVC anchors
| SGRQ total score | |||||
| Worsened ≥10 | Worsened 5–10 | Within 4.9 points | Improved 5–10 | Improved ≥10 | |
| Baseline to 6 months | n=16 −39.0 (128.2) | n=19 −6.6 (77.3) | n=36 8.0 (58.6) | n=16 15.8 (47.1) | n=34 2.9 (76.7) |
| 6–12 months | n=17 −84.6 (111.2) | n=20 −20.2 (49.0) | n=48 −10.4 (67.4) | n=14 25.9 (58.4) | n=24 5.6 (57.9) |
| FVC | |||||
| Declined ≥12% | Declined 7–12% | No change | Improved 7–12% | Improved ≥12% | |
| Baseline to 6 months | n=17 −56.1 (111.9) | n=24 −20.6 (105.4) | n=65 11.7 (49.6) | n=9 8.8 (35.6) | n=8 56.8 (43.1) |
| 6–12 months | n=18 −33.8 (74.1) | n=23 −51.6 (99.8) | n=71 −2.4 (65.2) | n=9 11.2 (56.9) | n=2 9.5 (67.2) |
Data are presented as mean (SD). Tests of significance for linear contrast in group effect yielded p=0.05 for baseline–6 months and p=0.0001 for 6–12 months for SGRQ Total and p=0.0003 for baseline–6 months and p=0.2 for 6–12 months for FVC.
FVC, forced vital capacity; 6MWD, 6 minute walk distance; 6MWT, 6 minute walk time; SGRQ, Saint George's Respiratory Questionnaire.