Table 1

Summary estimates of test characteristics of interferon-gamma release assays and tuberculin skin tests based on adult studies using healthy low-risk subjects as controls

TestsSets of dataCasesControlsMethod of meta-analysisMean sensitivity % (95% CI)Mean specificity % (95% CI)Mean PLR (95% CI)Mean NLR (95% CI)Mean DOR (95% CI)
QFT-G (E4–E7, E12)/ QFT-G-IT (E6) (based on Japanese studies)6443718Bivariate random effects model89 (84 to 93)98 (96 to 99)48.1 (19.7 to 117.6)0.11 (0.07 to 0.18)436.5 (159.5 to 1194.8)
Univariate random effects model89 (85 to 93)98 (97 to 99)43.4 (24.8 to 75.9)0.11 (0.08 to 0.16)460.0 (237.8 to 889.7)
QFT-G (E1–E3, E8–11)/ QFT-G-IT (E3, E13, E14) (based on other studies)10433498Bivariate random effects model79 (72 to 84)93 (86 to 96)10.8 (5.3 to 21.8)0.23 (0.16 to 0.32)47.6 (21.5 to 105.3)
Univariate random effects model79 (75 to 84)90 (84 to 96)11.6 (5.3 to 25.6)0.24 (0.18 to 0.31)46.9 (23.2 to 94.9)
T-SPOT.TB (E7, E8, E11, E12, E15, E16)6364363Bivariate random effects model91 (85 to 94)88 (78 to 94)7.9 (3.6 to 17.3)0.10 (0.06 to 0.18)75.6 (29.0 to 197.3)
Univariate random effects model92 (86 to 97)87 (83 to 92)6.7 (4.8 to 9.4)0.09 (0.04 to 0.19)116.7 (41.6 to 327.0)
TST-BCG (5 mm) (E4, E8, E11, E12)4282341Bivariate random effects model74 (64 to 83)40 (22 to 60)1.2 (0.6 to 2.4)0.65 (0.33 to 1.29)1.9 (0.7 to 5.0)
Univariate random effects model75 (63 to 86)43 (16 to 69)1.3 (0.8 to 2.2)0.70 (0.28 to 1.75)1.9 (0.4 to 8.5)
TST-BCG (10 or 15 mm) (E5, E8, E10, E11)7474604Bivariate random effects model66 (56 to 74)70 (55 to 81)2.2 (1.1 to 4.1)0.49 (0.32 to 0.76)4.4 (2.0 to 9.4)
Univariate random effects model64 (52 to 75)71 (58 to 85)2.2 (1.4 to 3.4)0.51 (0.36 to 0.73)4.6 (2.0 to 10.4)
  • DOR, diagnostic odds ratio; NLR, negative likelihood ratio; NA, not applicable; PLR, positive likelihood ratio; QFT-G, QuantiFERON-TB Gold; QFT-G-IT, QuantiFERON-TB Gold in-Tube; TST-BCG (x mm), tuberculin skin test with cut-off at x mm among predominantly BCG-vaccinated subjects.