Medical history
| All (382) | Belfast (95) | Brompton (99) | Leicester (79) | Manchester (109) | ||
| Family history of asthma (%) | ||||||
| Yes | 193 (50.5) | 70 (73.7) | 44 (44.4) | 33 (41.8) | 46 (42.2) | p<0.001 |
| No | 168 (44.0) | 24 (25.3) | 54 (54.5) | 33 (41.8) | 57 (52.3) | |
| Missing | 21 (5.5) | 1 (1.0) | 1 (1.0) | 13 (16.4) | 6 (5.5) | |
| Family history of asthma death (%) | ||||||
| Yes | 12 (3.1) | 5 (5.3) | 3 (3.0) | 0 | 4 (3.7) | p=0.439 |
| No | 175 (45.8) | 63 (66.3) | 40 (40.4) | 31 (39.2) | 41 (37.6) | |
| Not recorded | 195 (51.0) | 27 (28.4) | 56 (56.6) | 48 (60.8) | 66 (58.7) | |
| Prior history of atopy (%) | ||||||
| Yes | 219 (57.3) | 58 (61.1) | 71 (71.7) | 48 (60.8) | 42 (38.5) | p<0.001 |
| No | 159 (41.6) | 37 (38.9) | 28 (28.3) | 31 (39.2) | 63 (57.8) | |
| Missing | 4 (1.1) | 0 | 0 | 0 | 4 (3.7) | |
| Perennial rhinitis (%) | ||||||
| Yes | 111 (29.0) | 44 (46.3) | 35 (35.4) | 17 (21.5) | 15 (13.8) | p<0.001 |
| No | 261 (68.3) | 50 (52.6) | 63 (63.5) | 62 (78.5) | 86 (78.9) | |
| Missing | 10 (2.6) | 1 (1.0) | 1 (1.0) | 0 | 8 (7.3) | |
| Seasonal rhinitis (%) | ||||||
| Yes | 140 (36.6) | 29 (30.5) | 48 (48.5) | 35 (44.3) | 28 (25.7) | p<0.001 |
| No | 231 (60.5) | 65 (68.4) | 50 (50.5) | 44 (55.7) | 72 (66.1) | |
| Missing | 11 (2.9) | 1 (1.0) | 1 (1.0) | 0 | 9 (8.2) | |
| Eczema (%) | ||||||
| Yes | 103 (27.0) | 27 (28.4) | 28 (28.3) | 24 (30.4) | 24 (22.0) | p=0.77 |
| No | 270 (70.7) | 68 (71.6) | 70 (70.7) | 55 (69.6) | 77 (70.6) | |
| Missing | 9 (2.4) | 0 | 1 (1.0) | 0 | 8 (7.3) | |
| Other atopic condition (%) (food hypersensitvity, anaphylaxis, etc.) | ||||||
| Yes | 53 (13.9) | 17 (17.9) | 8 (8.1) | 20 (25.3) | 8 (8.1) | p=0.002 |
| No | 320 (83.8) | 78 (82.1) | 90 (90.9) | 59 (74.7) | 93 (84.7) | |
| Missing | 9 (2.4) | 0 | 1 (1.0) | 0 | 8 (7.2) | |
| Prior nasal surgery (%) | ||||||
| Yes | 55 (14.4) | 20 (21.1) | 20 (20.2) | 8 (10.1) | 7 (6.4) | p=0.009 |
| No | 316 (82.7) | 75 (78.9) | 78 (78.8) | 70 (88.6) | 93 (85.3) | |
| Missing | 11 (2.9) | 0 | 1 (1.0) | 1 (1.3) | 9 (8.3) | |
| Nasal polyps (%) | ||||||
| Yes | 51 (13.4) | 13 (13.7) | 13 (13.1) | 12 (15.2) | 13 (11.9) | p=0.98 |
| No | 321 (84.0) | 82 (86.3) | 85 (85.9) | 67 (84.8) | 87 (79.8) | |
| Missing | 10 (2.6) | 0 (0) | 1 (1.0) | 0 | 9 (8.3) | |
| History of oesophageal reflux (%) | ||||||
| Yes | 158 (41.4) | 56 (58.9) | 44 (44.4) | 24 (30.4) | 34 (31.2) | p<0.001 |
| No | 214 (56.0) | 39 (41.1) | 54 (54.5) | 54 (68.4) | 67 (61.5) | |
| Missing | 10 (2.6) | 0 | 1 (1.0) | 1 (1.3) | 8 (7.3) | |
| Prior OGD (%) | 17 (3.7) | 6 (6.3) | 5 (5.0) | 4 (5.1) | 2 (1.8) | p=0.51 |
| Prior pH profile (abnormal profile) | 36 (19) | 13 (6) | 19 (11) | 1 (0) | 3 (2) | p=0.62 |
| Significant catamennial asthma (%) | 16 of 188 women (8.5) | 4 of 41 (9.8) | 5 of 55 (9.1) | 2 of 34 (5.9) | 5 of 58 (8.6) | p=0.939 |
Group data, n (%) for all subjects, are presented in column 2 followed by data for individual centres. Between-centre comparisons were made using χ2 exact testing.
Significance was taken as p<0.01.
OGD, oesophagogastroduodenoscopy.