Mean percentage change in FVC and FEF25–75 between treatments, adjusted for baseline
| Pretreatment (litres) | Post-treatment (litres) | Comparison with RhDNase alone (litres) | ||
| Mean (SD) | Mean (SD) | Difference (95% CI) | p Value* | |
| FVC | ||||
| RhDNase alone | 2.25 (0.79) | 2.39 (0.74) | ||
| Mannitol alone | 2.37 (0.76) | 2.54 (0.78) | +0.14 (−0.00 to +0.29) | 0.053 |
| Mannitol + rhDNase | 2.31 (0.61) | 2.31 (0.81) | −0.07 (−0.30 to +0.16) | 0.52 |
| FEF25–75 | ||||
| RhDNase alone | 1.12 (0.63) | 1.17 (0.65) | ||
| Mannitol alone | 1.18 (0.64) | 1.21 (0.65) | −0.01 (−0.22 to +0.20) | 0.91 |
| Mannitol + rhDNase | 1.18 (0.49) | 1.26 (0.65) | +0.03 (−0.18 to +0.25) | 0.76 |
*p values derived from regression analysis.
FEF, forced expiratory flow; FVC, forced vital capacity; rhDNase, recombinant human deoxyribonuclease.