Table 4

Association between the NOS2A promoter haplotypes and new-onset asthma or FEV1 growth, by GSTM1 genotype

HaplotypeGSTM1New-onset asthma8-year growth in FEV1
HR (95% CI)*Interaction p value‡Estimate (95% CI)†Interaction p value‡
At least onePresent0.89 (0.58 to 1.37)−4.64 (−50.20 to 40.91)
At least oneNull1.89 (1.34 to 2.60)−53.19 (−99.63 to −6.75)
At least onePresent0.85 (0.54 to 1.34)39.85 (−5.81 to 85.50)
At least oneNull0.68 (0.48 to 0.98)49.75 (1.60 to 97.91)
  • * HR and 95% CI are based on fitting the Cox proportional hazard model (for details see the Methods section).

  • Estimate and 95% CI are based on the hierarchical mixed-effects model (for details see the Methods section).

  • Interaction p value was based on a likelihood ratio test by comparing models with and without interaction terms.

  • FEV1, forced expiratory volume in 1 s.