Haplotype | GSTM1 | New-onset asthma | 8-year growth in FEV_{1} | |||

HR (95% CI)* | Interaction p value‡ | Estimate (95% CI)† | Interaction p value‡ | |||

h0111101 | None | Present | Ref. | 0.002 | Ref. | 0.32 |

At least one | Present | 0.89 (0.58 to 1.37) | −4.64 (−50.20 to 40.91) | |||

None | Null | Ref. | Ref. | |||

At least one | Null | 1.89 (1.34 to 2.60) | −53.19 (−99.63 to −6.75) | |||

h1000010 | None | Present | Ref. | 0.42 | Ref. | 0.53 |

At least one | Present | 0.85 (0.54 to 1.34) | 39.85 (−5.81 to 85.50) | |||

None | Null | Ref. | Ref. | |||

At least one | Null | 0.68 (0.48 to 0.98) | 49.75 (1.60 to 97.91) |

↵* HR and 95% CI are based on fitting the Cox proportional hazard model (for details see the Methods section).

↵† Estimate and 95% CI are based on the hierarchical mixed-effects model (for details see the Methods section).

↵‡ Interaction p value was based on a likelihood ratio test by comparing models with and without interaction terms.

FEV

_{1}, forced expiratory volume in 1 s.