Association between the NOS2A promoter haplotypes and new-onset asthma or FEV1 growth, by GSTM1 genotype
| Haplotype | GSTM1 | New-onset asthma | 8-year growth in FEV1 | |||
| HR (95% CI)* | Interaction p value‡ | Estimate (95% CI)† | Interaction p value‡ | |||
| h0111101 | None | Present | Ref. | 0.002 | Ref. | 0.32 |
| At least one | Present | 0.89 (0.58 to 1.37) | −4.64 (−50.20 to 40.91) | |||
| None | Null | Ref. | Ref. | |||
| At least one | Null | 1.89 (1.34 to 2.60) | −53.19 (−99.63 to −6.75) | |||
| h1000010 | None | Present | Ref. | 0.42 | Ref. | 0.53 |
| At least one | Present | 0.85 (0.54 to 1.34) | 39.85 (−5.81 to 85.50) | |||
| None | Null | Ref. | Ref. | |||
| At least one | Null | 0.68 (0.48 to 0.98) | 49.75 (1.60 to 97.91) | |||
↵* HR and 95% CI are based on fitting the Cox proportional hazard model (for details see the Methods section).
↵† Estimate and 95% CI are based on the hierarchical mixed-effects model (for details see the Methods section).
↵‡ Interaction p value was based on a likelihood ratio test by comparing models with and without interaction terms.
FEV1, forced expiratory volume in 1 s.