Table 1

Summary of exposure by population

PopulationNo of studiesSalmeterol-containing productComparator
No of subjectsTotal exposure (years)No of subjectsTotal exposure (years)
Salmeterol-containing product vs non-LABA21557607205734896818433
Salmeterol vs placebo (without ICS)549463378789323682
Salmeterol + ICS (BK/RD)* vs ICS (BK/RD)*12724542102852417310243
Fluticasone/salmeterol combination (RD)† vs ICS (RD)†63114375020111635008
  • *BK/RD, ICS received as background medication or as randomised study drug.

  • †RD, ICS received as randomised study drug.

  • ICS, inhaled corticosteroid; LABA, long-acting β agonist.