Study design and proportion of the 47 children in the RSV cohort and the 93 in the control cohort seen at follow-up during the study period
Age (years) | ||||||
1 | 1.5, 2 and 2.5 | 3 | 7 | 13 | 18 | |
Total number (RSV, controls) | 47, 93 | 47, 93 | 47, 93 | 47, 93 | 46, 92 | 46, 92 |
% of cohort (RSV and controls) | 100 | 100 | 100 | 100 | 98.5 | 98.5 |
Questionnaire | × | × | × | × | × | × |
Examination | × | × | × (46, 89) | × (45, 89) | × (42, 87) | |
Skin prick tests (RSV, controls) | × (47, 92) | × (45, 92) | × (44, 89) | × (42, 87) | × (41, 85) | |
Egg white | × | × | × | |||
Cat | × | × | × | × | ||
Dog | × | × | × | |||
Horse | × | × | × | |||
Birch | × | × | × | × | ||
Timothy | × | × | × | |||
Mugworth | × | × | ||||
HDM (D pteronyssinus) | × | × | × | × | ||
HDM (D farinae) | × | × | ||||
Mould (Cladosporium herbarum) | × | × | × | |||
Mould (Alternaria alternata) | × | × | ||||
Blood samples | × | × (44, 87) | × (44, 86) | × (41, 85) | ||
IgE to food allergens (Fx5) | × | × | ||||
IgE to inhaled allergens (Phadiatop) | × | × | × | × (41, 85) | ||
Blood eosinophil counts | × (40, 86) | |||||
Lung function tests | × (44, 86) | × (44, 86) | × (42, 86) | |||
Spirometry | × | × | × | |||
Multiple breath washout (LCI) | × (41, 86) | |||||
FeNO | × (42, 86) | |||||
DACh | × (43, 86) | × (41, 86) |
Numbers in parentheses (RSV, controls) if differed from numbers followed up at that time point.
A skin prick test weal with a mean diameter ≥3 mm was regarded positive. Phadiatop (Pharmacia Upjohn Diagnostics AB, Uppsala, Sweden) is a screening test for antibodies to inhaled allergens. Fx5 (Pharmacia Upjohn Diagnostics AB, Uppsala, Sweden) is a screening test for food allergens.
HDM, house dust mite; DACh, dry air hyperventilation challenge; LCI, lung clearance index; FeNO, fractional exhaled nitric oxide; RSV, respiratory syncytial virus.