Table 2

Hepatic risks of chemoprophylaxis

ReferenceNHepatitis/100000*% CompletionComments
Regimen 6H
IUALTD269654807865% protective efficacy (one death from 6H)
Jasmer3282100059
Nolan411141100–Female OR 3.3 (95% CI 0.87 to 12.45)
White OR 2.60 (95% CI 0.75 to 8.95)
Increase with age χ2 5.22 (p=0.02)
Bailey54271170
Weighted average18815278
Regimen 3RH
HK TB Service61701766–50% protective efficacy in silicosis
Regimen 4-6R
Menzies741871778
Regimen 2RZ
Lee8148945957Female OR 4.1 (95% CI 1.2 to 14.3)
Recent conversion OR 14.3 (95% CI 1.8 to 115)
Jasmer3307770061Age >35 OR 12.2 (95% CI 1.49 to 100.3)
OR 8.46 × isoniazid (95% CI 1.9 to 76.5)
Stout9114530067.5
Weighted average5696648

  • Adapted from reference 10 with permission.

  • ↵* Symptomatic or grade 3/4 hepatitis.

  • H, isoniazid; R, rifampicin; Z, pyrazinamide.