Variables | HR | 95% CI | p Value |
Gender | |||
Female | 1 | ||
Male | 1.905 | 1.112 to 3.257 | 0.019 |
Smoking index, pack-years* | 1.008 | 1.000 to 1.016 | 0.040 |
Histological type | |||
Non-squamous cell carcinoma | 1 | ||
Squamous cell carcinoma | 1.802 | 1.183 to 2.740 | 0.006 |
Disease-free interval, months | |||
≤16 | 1 | ||
>16 | 0.462 | 0.295 to 0.721 | 0.001 |
Lung metastasis | |||
Absent | 1 | ||
Present | 0.596 | 0.367 to 0.968 | 0.037 |
Brain metastasis | |||
Absent | 1 | ||
Present | 0.828 | 0.536 to 1.279 | 0.394 |
Bone metastasis | |||
Absent | 1 | ||
Present | 1.553 | 1.016 to 2.375 | 0.042 |
Liver metastasis | |||
Absent | 1 | ||
Present | 1.321 | 0.733 to 2.380 | 0.354 |
Treatment for distant metastasis | |||
No | 1 | ||
Yes | 0.253 | 0.129 to 0.494 | <0.001 |
↵* The HR associated with the smoking index is an increased hazard per 1 pack-year of additional smoking.