Demographic and clinical characteristics of the discovery and test populations
| Discovery population | Test population | |
| Number of subjects | 76 | 55 |
| Age (years) | 3.10 (1.30–4.40) | 3.60 (1.90–5.00) |
| Males | 41 (53.9%) | 37 (67.3%) |
| Age first paired sample (years) | 1.31 (0.30–3.30) | 0.39 (0.33–0.48) |
| P aeruginosa ≥105 cfu/ml in BAL culture | Positive serology | P aeruginosa ≥105 cfu/ml in BAL culture | Positive serology | |||
| MAg | ExoA | MAg | ExoA | |||
| N (%) | 15/76 (19.7%) | 38 (50%) | 30 (39.5%) | 16/55 (29.1%) | 19 (34.5%) | 33 (60%) |
| Age first detected (range) (years) | 1.88 (1.05–4.30) (0.56–5.95) | 1.30 (1.70–2.00) (1.00–3.00) | 1.20 (1.10–1.30) (0.10–3.00) | 1.86 (1.31–2.97) (0.33-4.76) | 3.70 (2.70–4.90) (1.10–5.10) | 2.20 (0.96–2.66) (0.33–4.3) |
| Persistent | 1/15 (6.7%) | 14/19* (73.7%) | 20/26* (76.9%) | 0/16 | 8/12* (66.7%) | 21/22* (95.5%) |
| Intermittent | 14/15 (93.3%) | 5/19 (26.3%) | 6/26 (23.1%) | 16/16 (100%) | 4/12 (33.3%) | 1 (4.5%) |
Results presented as median (25th–75thcentile) unless otherwise specified.
↵* Subjects with >2 consecutive serology samples.
BAL, bronchoalveolar lavage; MAg, multiple blended P aeruginosa antigens; ExoA, P aeruginosa exotoxin A antigen.