Table 2

Clinical characteristics of children with hypertrypsinaemia (HIRT) at birth and at follow-up according to the diagnostic score cut-off

NPD diagnosis score>0.27≤0.27p Value
No. of patients813
At birth
IRT (day 3)105 (25)81 (69)0.43
Birth weight (g)2970 (1357)3380 (517)0.14
At evaluation
Age (years)1.7 (2.9)2 (1.8)0.56
Sweat Cl (mmol/l)46(17)33 (9)0.03
Recurrent lower tract infection*3/88/130.38
Transient isolation of S. aureus1/84/130.6
BMI Z score−1.6 (1.5)−1 (2.3)0.06
At follow-up
Age (years)3.4 (3)4.1 (1.4)0.88
Sweat test >60 mmol/l0/56/90.03
Sweat Cl (mmol/l)18 (14.5); n=564 (36); n=90.004
Recurrent lower tract infection*0/88/130.007
Chronic P aeruginosa0/81/130.9
Chronic S aureus0/83/130.25
Transient isolation of P aeruginosa0/82/130.5
Transient isolation of S aureus3/84/130.9
Airway obstruction1/84/130.6
BMI Z-score−1.2 (1.6)0 (2)0.04
Pancreatic insufficiency0/81/130.99
Alternative diagnosis6/80/130.0005
  • Results are presented as median (IQR) or number of observations. Comparison with Fisher exact test for qualitative variables and Mann–Whitney test for quantitative variables.

    Patients with HIRT-Nl have a diagnostic score >0.27, patients with HIRT-CF have a diagnostic score <0.27.

  • * At least four episodes per week requiring modification of basal treatment.

  • BMI, body mass index; CF, cystic fibrosis; IRT, immunoreactive trypsinogen; NPD, nasal potential difference.