Table 2

Univariate analysis of variance comparing mean 25-OHD serum levels according to the different genotypes of the vitamin D-binding gene (GC)

rs NumberGenotypeSubjects, n (%)Serum 25-OHD mean±SDp Value
COPDrs7041GG85 (34)22.1±7.8Reference
GT108 (43)20.0±7.00.12
TT60 (23)16.7±7.2<0.0001
rs4588CC128 (51)21.0±7.9Reference
CA109 (43)19.2±7.00.15
AA16 (6)15.6±7.20.01
Controlsrs7041GG54 (36)26.3±8.7Reference
GT73 (49)24.6±9.10.5
TT23 (15)20.9±5.00.03
rs4588CC88 (59)25.8±8.8Reference
CA49 (33)23.8±8.60.09
AA13 (8)20.6±4.60.09
  • Univariate analysis of variance (ANOVA) with a Tukey–Kramer posthoc test was performed to calculate the mean 25-hydroxyvitamin D (25-OHD) serum levels (ng/ml) stratified according to rs7041 and rs4588 genotypes in patients with chronic obstructive pulmonary disease (COPD) (n=253) and controls (n=150). p Values indicate significance of the genotypes relative to wild-type genotypes.