Time | ES=0.5 | ΔFVC=7–12% | ΔSGRQt=5–10 | Regression equation for FVC | Regression equation for SGRQt | Mean |

Baseline to 6 months | 41.3 m | 17.4 m* | 10.8 m | Δ6MWD=2.6+1.9 (ΔFVC) Corresponding to 10% change in raw FVC, Δ6MWD=21.6 (8.6–33.6)
| Δ6MWD=−4 +(−1.2)(ΔSGRQt) Corresponding to 7 unit change in SGRQt, Δ6MWD=12.4 (5.4–19.4)
| 20.7 |

6–12 months | 58.5 m | 40.2 m* | 22.5 m | Δ6MWD=−6.1+2.9(ΔFVC) Corresponding to 10% change in raw FVC, Δ6MWD=22.9 (6.9 to 39.9)
| Δ6MWD=−1.9 +(−4.4)(ΔSGRQt) Corresponding to 7 unit change in SGRQt, Δ6MWD=32.7 (25 to 41.1)
| 35.4 |

Grand mean=28, thus MID=28 m.

The 95% CIs around the MID estimates from the regression equations are sample size dependent. The point estimates should be viewed as the best estimates of the MID.

↵* Weighted mean of subjects whose raw FVC changed by 7–12% over the indicated time interval.

ES, effect size; FVC, forced vital capacity; MID, minimum important difference; 6MWD, 6 minute walk distance; SGRQt, Saint George's Respiratory Questionnaire SGRQ Total.