Table 2 Risk of atopy (positive specific immunoglobulin E) at age 45 and SNPs in asthma candidate genes

Gene; SNP	Alleles			Homozygote allele 1	Heterozygote	Homozygote allele 2	2df p Value	1df p Value	OR (per allele)	95% CI for OR
Gene; SNP	1	2		N	n	n	2df p Value	1df p Value	OR (per allele)	95% CI for OR
Ptgdrs2_441	G	A	Case	135	824	1068	0.938	0.841	1.01	0.93 to 1.10
Ptgdrs2_441	G	A	Control	343	2050	2710	0.938	0.841	1.01	0.93 to 1.10
Ptgdrs3_197	A	G	Case	1567	426	32	0.769	0.747	1.02	0.91 to 1.14
Ptgdrs3_197	A	G	Control	3935	1111	74	0.769	0.747	1.02	0.91 to 1.14
Ptgdrs rs17125273	G	A	Case	25	396	1604	0.610	0.332	0.94	0.84 to 1.06
Ptgdrs rs17125273	G	A	Control	73	1033	3982	0.610	0.332	0.94	0.84 to 1.06
DPP10 rs13011555	C	T	Case	249	941	829	0.913	0.834	1.01	0.93 to 1.09
DPP10 rs13011555	C	T	Control	634	2350	2119	0.913	0.834	1.01	0.93 to 1.09
DPP10 rs13392783	G	A	Case	736	977	304	0.478	0.390	1.03	0.96 to 1.11
DPP10 rs13392783	G	A	Control	1838	2428	827	0.478	0.390	1.03	0.96 to 1.11
DPP10 rs1430091	G	T	Case	1218	697	94	0.421	0.478	1.03	0.95 to 1.13
DPP10 rs1430091	G	T	Control	3055	1736	276	0.421	0.478	1.03	0.95 to 1.13
DPP10 rs17048359	C	T	Case	206	880	911	0.378	0.165	0.95	0.88 to 1.02
DPP10 rs17048359	C	T	Control	560	2270	2219	0.378	0.165	0.95	0.88 to 1.02
DPP10 rs4241129	T	A	Case	803	839	203	0.574	0.552	1.03	0.95 to 1.11
DPP10 rs4241129	T	A	Control	2026	2092	557	0.574	0.552	1.03	0.95 to 1.11
DPP10 rs48493333	C	T	Case	128	777	1098	0.842	0.629	0.98	0.90 to 1.07
DPP10 rs48493333	C	T	Control	343	1971	2760	0.842	0.629	0.98	0.90 to 1.07
PHF11 rs2274282	G	T	Case	1457	495	40	0.675	0.474	0.96	0.87 to 1.07
PHF11 rs2274282	G	T	Control	3717	1233	87	0.675	0.474	0.96	0.87 to 1.07
PHF11 rs6561533	G	A	Case	651	914	392	0.512	0.435	1.03	0.96 to 1.11
PHF11 rs6561533	G	A	Control	1571	2366	991	0.512	0.435	1.03	0.96 to 1.11
PHF11 rs6561539	G	C	Case	53	508	1449	0.305	0.909	1.01	0.91 to 1.11
PHF11 rs6561539	G	C	Control	107	1337	3659	0.305	0.909	1.01	0.91 to 1.11
GPRA rs323917	C	G	Case	1762	240	6	0.912	0.710	0.97	0.84 to 1.13
GPRA rs323917	C	G	Control	4461	593	13	0.912	0.710	0.97	0.84 to 1.13
GPRA rs323922	G	C	Case	322	963	730	0.458	0.616	0.98	0.91 to 1.06
GPRA rs323922	G	C	Control	796	2518	1781	0.458	0.616	0.98	0.91 to 1.06
GPRA rs324377	C	A	Case	389	986	640	0.229	0.987	1.00	0.93 to 1.08
GPRA rs324377	C	A	Control	926	2605	1562	0.229	0.987	1.00	0.93 to 1.08
GPRA rs324396	C	T	Case	929	892	195	0.798	0.524	1.03	0.95 to 1.11
GPRA rs324396	C	T	Control	2304	2287	505	0.798	0.524	1.03	0.95 to 1.11
GPRA rs740347	G	C	Case	43	492	1481	0.431	0.722	1.02	0.92 to 1.13
GPRA rs740347	G	C	Control	86	1265	3743	0.431	0.722	1.02	0.92 to 1.13
ADAM33 rs511898	C	T	Case	871	898	237	0.290	0.139	0.94	0.87 to 1.02
ADAM33 rs511898	C	T	Control	2279	2261	541	0.290	0.139	0.94	0.87 to 1.02
ADAM33 rs528557	C	G	Case	1100	801	141	0.396	0.242	1.05	0.97 to 1.14
ADAM33 rs528557	C	G	Control	2831	2008	314	0.396	0.242	1.05	0.97 to 1.14
ADAM33 rs574174	C	T	Case	1357	605	59	0.850	0.608	1.03	0.93 to 1.13
ADAM33 rs574174	C	T	Control	3398	1542	160	0.850	0.608	1.03	0.93 to 1.13
ADAM33 rs612709	G	A	Case	37	483	1512	0.841	0.781	1.01	0.91 to 1.13
ADAM33 rs612709	G	A	Control	83	1218	3814	0.841	0.781	1.01	0.91 to 1.13

The 2df test relates to whether incidence varies across the three genotypes (without an assumed genetic model). The 1df test assumes a per-allele (additive) model.
SNP, single nucleotide polymorphism.