| Phenotypes | Inflammatory patterns | Eosinophilic vs non-eosinophilic pattern* | |
| Non-eosinophilic pattern (n = 214) | Eosinophilic pattern (n = 167) | ||
| EOSlo/NEUhi (n = 48) vs EOSlo/NEUlo (n = 166)* | EOShi/NEUhi (n = 35) vs EOShi/NEUlo (n = 132)† | ||
| Positive skin prick test response | 0.44 (0.20 to 0.96) | 1.09 (0.18 to 6.48) | 1.38 (0.84 to 2.26) |
| BHR, PD20⩽4 mg | 0.83 (0.31 to 2.21) | 0.29 (0.01 to 8.30) | 7.21 (2.70 to 19.2) |
| Asthma attack (last 12 months) | 0.77 (0.38 to 1.52) | 0.72 (0.24 to 2.16) | 1.89 (1.15 to 3.12) |
| Nocturnal symptoms (last 12 months): | |||
| Woken by an attack of shortness of breath | 0.95 (0.47 to 1.90) | 1.65 (0.67 to 4.07) | 2.17 (1.41 to 3.32) |
| Woken with chest tightness | 0.82 (0.42 to 1.59) | 5.06 (1.04 to 24.6) | 2.54 (1.55 to 4.16) |
| Woken by an attack of coughing | 1.06 (0.51 to 2.22) | 2.25 (0.95 to 5.33) | 1.13 (0.73 to 1.75) |
| At least two nocturnal symptoms | 0.88 (0.45 to 1.74) | 5.21 (1.44 to 18.8) | 2.38 (1.52 to 3.72) |
| Attack of coughing excluded | 0.91 (0.29 to 2.92) | 4.99 (1.07 to 23.3) | 2.45 (1.30 to 4.62) |
| COPD-like symptoms: | |||
| Chronic cough | 1.26 (0.54 to 2.93) | 1.46 (0.52 to 4.07) | 0.94 (0.54 to 1.63) |
| Chronic phlegm | 1.28 (0.49 to 3.38) | 1.69 (0.54 to 5.34) | 0.95 (0.58 to 1.94) |
| Dyspnoea grade 3 | 1.95 (0.85 to 4.51) | 1.74 (0.69 to 4.36) | 1.62 (0.95 to 2.77) |
Results are expressed as ORs (95% CI).
*Adjusted for age, sex and smoking, and taking into account familial dependence of the subjects.
†Adjusted for age, sex, smoking and inhaled corticosteroid treatment, and taking into account familal dependence of the subjects.
BHR, bronchial hyper-responsiveness; COPD, chronic obstructive pulmonary disease; EOS, eosinophils; NEU, neutrophils; PD20, dose of methacholine causing a 20% drop in FEV1 (forced expiratory volume in 1 s).