Table 2 Median (25th to 75th percentile) of cytokines and markers according to initial severity | PSI | p Value |
I–II | III | IV | V |
CRP (mg/dl) | 15.9 (7.8–24.3) | 13.6 (5.8–20.4) | 15.5 (8.2–26.2) | 18.7 (8.7–28.3) | 0.2 |
PCT (ng/ml) | 0.43 (0.2–1.5) | 0.43 (0.25–1.6) | 0.74 (0.3–2.8) | 2.2 (0.8–11.8) | 0.001 |
IL6 (pg/ml) | 72 (26–202) | 79 (34–208) | 66 (28–185) | 134 (41–383) | 0.08 |
IL8 (pg/ml) | 6 (0–17) | 5 (2–11) | 5 (1–16) | 14 (4–32) | 0.01 |
IL10 (pg/ml) | 5 (1–15) | 8 (2–20) | 9 (2–23) | 10 (0–36) | 0.07 |
| CURB65 | CRB65 |
0–1 | 2 | ⩾3 | p Value | 0–1 | 2 | ⩾3 | p Value |
CRP (mg/dl) | 14.9 (7.1–23.4) | 15.4 (8.7–23.7) | 16.9 (7.6–27.7) | 0.4 | 15.2 (7.1–23.5) | 15.1 (8.4–22.7) | 21.5 (8.5–30.5) | 0.08 |
PCT (ng/ml) | 0.41 (0.24–1.4) | 0.86 (0.29–4.3) | 1.46 (0.44–6.2) | 0.001 | 0.43 (0.23–1.71) | 0.95 (0.37–3.59) | 2.79 (0.92–16.15) | 0.0001 |
IL6 (pg/ml) | 71 (34–179) | 79 (29–236) | 93 (28–315) | 0.5 | 71 (30–174) | 77 (30–214) | 137 (30–432) | 0.054 |
IL8 (pg/ml) | 6 (1–14) | 5 (2–15) | 9 (2–31) | 0.02 | 6 (2–15) | 5 (2–16) | 13 (2–36) | 0.093 |
IL10 (pg/ml) | 5 (1–17) | 10 (3–31) | 9 (1–22) | 0.04 | 5 (1–18) | 9 (2–23) | 11 (5–40) | 0.005 |