Table 2 Median (25th to 75th percentile) of cytokines and markers according to initial severity
PSIp Value
I–IIIIIIVV
CRP (mg/dl)15.9 (7.8–24.3)13.6 (5.8–20.4)15.5 (8.2–26.2)18.7 (8.7–28.3)0.2
PCT (ng/ml)0.43 (0.2–1.5)0.43 (0.25–1.6)0.74 (0.3–2.8)2.2 (0.8–11.8)0.001
IL6 (pg/ml)72 (26–202)79 (34–208)66 (28–185)134 (41–383)0.08
IL8 (pg/ml)6 (0–17)5 (2–11)5 (1–16)14 (4–32)0.01
IL10 (pg/ml)5 (1–15)8 (2–20)9 (2–23)10 (0–36)0.07
CURB65CRB65
0–12⩾3p Value0–12⩾3p Value
CRP (mg/dl)14.9 (7.1–23.4)15.4 (8.7–23.7)16.9 (7.6–27.7)0.415.2 (7.1–23.5)15.1 (8.4–22.7)21.5 (8.5–30.5)0.08
PCT (ng/ml)0.41 (0.24–1.4)0.86 (0.29–4.3)1.46 (0.44–6.2)0.0010.43 (0.23–1.71)0.95 (0.37–3.59)2.79 (0.92–16.15)0.0001
IL6 (pg/ml)71 (34–179)79 (29–236)93 (28–315)0.571 (30–174)77 (30–214)137 (30–432)0.054
IL8 (pg/ml)6 (1–14)5 (2–15)9 (2–31)0.026 (2–15)5 (2–16)13 (2–36)0.093
IL10 (pg/ml)5 (1–17)10 (3–31)9 (1–22)0.045 (1–18)9 (2–23)11 (5–40)0.005
  • CRB65, Confusion, Respiratory rate, Blood pressure, ≥65 years of age; CRP, C-reactive protein; CURB65, Confusion, Urea nitrogen, Respiratory rate, Blood pressure, ≥65 years of age; IL, interleukin; PCT, procalcitonin; PSI, Pneumonia Severity Index.