Associations of UGT1A1 tagging single nucleotide polymorphisms (SNPs) with serum total bilirubin levels in patients with sepsis: linear regression analysis
| LD block | Tagging SNPs | Bilirubin levels by genotypes* | Univariate analysis | Stepwise multivariate analysis | ||||||
| 0 | 1 | 2 | Estimates (SE) | p Value | FDR p | Estimates (SE) | p Value | FDR p | ||
| Block 1 | rs3755319 | 282 | 513 | 204 | ||||||
| 1.64 (0.26) | 1.62 (0.16) | 1.86 (0.24) | 0.0534 (0.0199) | 0.0073 | 0.024 | 0.0493 (0.0171) | 0.0043 | 0.005 | ||
| rs887829 | 438 | 455 | 108 | |||||||
| 1.60 (0.19) | 1.60 (0.18) | 2.26 (0.37) | 0.0694 (0.0208) | 0.0009 | 0.0045 | 0.0609 (0.0178) | 0.0001 | 0.0005 | ||
| rs6742078 | 436 | 456 | 109 | |||||||
| 1.58 (0.18) | 1.60 (0.18) | 2.18 (0.37) | 0.0709 (0.0207) | 0.0006 | 0.0045 | 0.0696 (0.0178) | 0.0001 | 0.0005 | ||
| rs3771342 | 757 | 227 | 21 | – | ||||||
| 1.75 (0.15) | 1.36 (0.13) | 2.02 (1.29) | −0.0220 (0.0282) | 0.436 | 0.110 | – | NS | – | ||
| rs17864705 | 870 | 122 | 8 | – | ||||||
| 1.64 (0.13) | 1.72 (0.30) | 4.61 (3.34) | 0.0608 (0.0375) | 0.105 | 0.210 | – | NS | – | ||
| rs1018124 | 870 | 114 | 7 | – | ||||||
| 1.68 (0.13) | 1.43 (0.19) | 4.50 (3.85) | 0.0172 (0.0390) | 0.660 | 0.943 | – | NS | – | ||
| Block 2 | rs11888492 | 773 | 218 | 13 | – | |||||
| Block 3 | 1.67 (0.14) | 1.58 (0.27) | 3.06 (1.70) | −0.0002 (0.0300) | 0.884 | 0.982 | – | NS | – | |
| rs8330 | 601 | 328 | 73 | – | ||||||
| 1.75 (0.17) | 1.41 (0.15) | 2.02 (0.58) | −0.0103 (0.0218) | 0.637 | 0.943 | – | NS | – | ||
| rs1500482 | 620 | 335 | 49 | – | ||||||
| 1.71 (0.17) | 1.45 (0.15) | 2.55 (0.84) | 0.0003 (0.0230) | 0.989 | 0.989 | – | NS | – | ||
| rs4663972 | 610 | 341 | 55 | – | ||||||
| 1.76 (0.17) | 1.35 (0.14) | 2.62 (0.77) | −0.0070 (0.0230) | 0.761 | 0.951 | – | NS | – | ||
Genotype 0, 1 and 2 represent the wild type, heterozygotes and homozygotes, respectively. Missing genotyping is not included.
*Data are n or mean (SD).
FDR, false discovery rate; LD, linkage disequilibrium.